Comparison of Blueberry (Vaccinium spp.) and Vitamin C via Antioxidative and Epigenetic Effects in Human

김민주; 나현경; Hiroshi Kasai; Kazuaki Kawai; Yun-Shan Li; 양미희

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자료유형: 학술저널

저자정보: 김민주 (숙명여자대학교) 나현경 (숙명여자대학교) Hiroshi Kasai (University of Occupational and Environmental Health Kitakyushu Japan) Kazuaki Kawai (University of Occupational and Environmental Health Kitakyushu Japan) Yun-Shan Li (University of Occupational and Environmental Health Kitakyushu Japan) 양미희 (숙명여자대학교)

저널정보: 대한암예방학회 대한암예방학회지 대한암예방학회지 제22권 제3호

발행연도: 2017.1

수록면: 174 - 181 (8page)

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Background: Chemopreventive effects and the underlying mechanisms of blueberry (Vaccinium spp.) are not clearly understood in human. We hypothesized blueberry would work via antioxidative and epigenetic modulation, which is similar to vitamin C. Methods: We performed a pilot and non-inferiority study in healthy young women (n = 12), who consumed vitamin C (1 g/d) or 240 mL of blueberry juice (total polyphenols 300 mg and proanthocyanidin 76 mg/d) for 2 weeks. We analyzed 8-hydroxydeoxyguanosine (8-OHdG) and malondialdehyde (MDA) levels in their urine, and global and specific DNA methylation at the NAD(P)H quinone oxidoreductase 1 (NQO1), methylenetetrahydrofolate reductase (MTHFR), or DNA methyltransferase 1 (DNMT1) genes in their blood. Results: Urinary 8-OHdG levels were reduced by blueberry consumption rather than by vitamin C. The methylation (%) of the MTHFR was significantly decreased in blueberry-consumers and the antioxidant-susceptible subgroup, whose urinary MDA levels were decreased by the intervention. We also found a positive correlation between changes of urinary 8-OHdG and of DNA methylation at the MTHFR or the DNMT1 (P ＜ 0.05). However, the genetic polymorphism of the MTHFR (C677T in exon 4) did not affect any above markers. Conclusions: Blueberry juice shows similar anti-oxidative or anti-premutagenic activity to vitamin C and the potential as a methylation inhibitor for the MTHFR and the DNMT1 in human.

참고문헌 (28)

참고문헌 신청

Kim M / 2012 / Environmental toxicants: induced epigenetic alterations and their reversers / J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 30:323~367

Haggarty P / 2013 / Epigenetic consequences of a changing human diet / Proc Nutr Soc 72:363~371

Nishida N / 2013 / Reactive oxygen species induce epigenetic instability through the formation of 8-hydroxydeoxyguanosine in human hepatocarcinogenesis / Dig Dis 31:459~466

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Yi B / 2011 / Inhibition by wheat sprout (Triticum aestivum) juice of bisphenol A-induced oxidative stress in young women / Mutat Res 724:64~68

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