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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 109 - 114 (6page)
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Purpose: Deep venous thrombosis (DVT) is a common but elusive condition characterized by a high morbidity and mortality rate. The aim of the present study was to investigate the correlation between methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism with plasma total homocysteine (tHcy) levels and DVT risk in an Iranian population. Materials and Methods: Our study population consisted of 67 patients with a diagnosis of DVT and 67 healthy subjects as controls. Genotyping of MTHFR C677T polymorphism was performed by the polymerase chain reaction technique combined with restriction enzyme fragment length polymorphism (PCR-RFLP) and measurement of tHcy levels was done by enzyme immunoassay method. Results: Plasma tHcy levels were significantly higher in DVT patients than controls (18.09±7.6 vs. 10.5±4.3, P=0.001). Also, plasma tHcy levels were significantly higher in MTHFR 677TT genotypes compared to 677CC genotypes in both DVT patients (P=0.016) and controls (P=0.03). Neither heterozygote nor homozygote genotypes of MTHFR C677T polymorphism was significantly correlated with DVT (P>0.05). The distribution of MTHFR C677T genotypes was similar between men and women in both DVT patients and controls (P>0.05). Moreover, the frequency of mutant 677T allele did not differ significantly between the two groups (28.3% vs. 21.6%, P=0.15). Conclusion: Based on this study, we propose that hyperhomocysteinemia but not homozygosity for MTHFR C677T polymorphism is a significant risk factor for DVT in the Iranian population. Also, MTHFR 677TT genotype is a determinant of elevated plasma tHcy levels.
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참고문헌 (25)
참고문헌 신청
Kesieme E / 2011 / Deep vein thrombosis: a clinical review / J Blood Med 2:59~69
Ghaffari K / 2015 / Correlation between C677T and A1298C mutat ions on the MTHFR gene with plasma homocysteine levels and venous thrombosis in pregnant women at risk of thrombosis / Zahedan J Res Med Sci
Brezovska-Kavrakova J / 2013 / Hyperhomocysteinemia and of methylenetetrahydrofolate reductase (c677t) genetic polymorphism in patients with deep vein thrombosis / Mater Sociomed 25:170~174
Mouravas H / 2010 / Homocysteine and its relationship to deep venous thrombos i s in patients undergoing total knee or hip arthroplasty / Hippokratia 14:185~188
Tsai AW / 2003 / Serum homocysteine, thermolabile variant of methylene tetrahydrofolate reductase (MTHFR), and venous thromboembol ism:longitudinal Investigation of Thromboembolism Etiology (LITE) / Am J Hematol 72:192~200
Ghaffari K / 2015 / Correlation between C677T and A1298C mutat ions on the MTHFR gene with plasma homocysteine levels and venous thrombosis in pregnant women at risk of thrombosis / Zahedan J Res Med Sci
Brezovska-Kavrakova J / 2013 / Hyperhomocysteinemia and of methylenetetrahydrofolate reductase (c677t) genetic polymorphism in patients with deep vein thrombosis / Mater Sociomed 25:170~174
Mouravas H / 2010 / Homocysteine and its relationship to deep venous thrombos i s in patients undergoing total knee or hip arthroplasty / Hippokratia 14:185~188
Tsai AW / 2003 / Serum homocysteine, thermolabile variant of methylene tetrahydrofolate reductase (MTHFR), and venous thromboembol ism:longitudinal Investigation of Thromboembolism Etiology (LITE) / Am J Hematol 72:192~200
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