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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 215 - 222 (8page)
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초록· 키워드
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Background: Currently, the hypertension (HTN) patients undergo appropriate medical treatment, and traditional risk factors are highly controlled. Therefore, potential risk factors of atherosclerotic vascular diseases (AVD) and venous thromboembolisms (VTE) in HTN should be reconsidered. We investigated thrombophilic genetic mutations and existing biomarkers for AVD or VTE in HTN patients receiving treatment.
Methods: A total of 183 patients were enrolled: AVD with HTN (group A, n=45), VTE with HTN (group B, n=62), and HTN patients without any vascular diseases (group C, n=76). The lipid profile, homocysteine (Hcy) levels, D-dimers, fibrinogen, antithrombin, lupus anticoagulant, and anti-cardiolipin antibody (aCL) were evaluated. Prothrombin G20210A, Factor V G1691A, and methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C were analyzed.
Results: All patients revealed wild type prothrombin G20210A and Factor V G1691A polymorphisms. The frequency of MTHFR polymorphisms was 677CT (n=84, 45.9%); 677TT (n=46, 25.1%); 1298AC (n=46, 25.1%); and 1298CC (n=2, 1.1%). The MTHFR 677TT genotype tended to increase the odds ratio (OR) to AVD events in HTN patients (OR 2.648, confidence interval 0.982-7.143, P=0.05). The group A demonstrated significantly higher Hcy levels (P=0.009), fibrinogen (P=0.004), and platelet counts (P=0.04) than group C. Group B had significantly higher levels of D-dimers (P=0.0001), platelet count (P=0.0002), and aCL (P=0.02) frequency than group C.
Conclusions: The MTHFR 677TT genotype and Hcy level could be potential risk factors associated with development of AVD in HTN patients receiving treatment. D-dimer and aCL might be useful to estimate the occurrence of VTE in them.
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참고문헌 (40)
참고문헌 신청
Guidelines Subcommittee / 1999 / 1999 World Health Organization-International Society of Hypertension Guidelines for the Management of Hypertension / J Hypertens 17:151~183
Kearney PM / 2005 / Global burden of hypertension: analysis of worldwide data / Lancet 365:217~223
Pedrinelli R / 2012 / Hypertension and acute myocardial infarction: an overview / J Cardiovasc Med (Hagerstown) 13:194~202
Gaciong Z / 2013 / Blood pressure control and primary prevention of stroke: summary of the recent clinical trial data and meta-analyses / Curr Hypertens Rep 15:559~574
Wolf PA / 1991 / Probability of stroke: a risk profile from the Framingham Study / Stroke 22:312~318
Kearney PM / 2005 / Global burden of hypertension: analysis of worldwide data / Lancet 365:217~223
Pedrinelli R / 2012 / Hypertension and acute myocardial infarction: an overview / J Cardiovasc Med (Hagerstown) 13:194~202
Gaciong Z / 2013 / Blood pressure control and primary prevention of stroke: summary of the recent clinical trial data and meta-analyses / Curr Hypertens Rep 15:559~574
Wolf PA / 1991 / Probability of stroke: a risk profile from the Framingham Study / Stroke 22:312~318
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