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논문 기본 정보

자료유형
학술저널
저자정보
Sadashiv (Department of Biochemistry All India Institute of Medical Sciences RaebareliIndia) Anupama Modi (Department of Biochemistry All India Institute of Medical Sciences Jodhpur Jodhpur) Manoj Khokhar (Department of Biochemistry All India Institute of Medical Sciences Jodhpur Jodhpur) Praveen Sharma (Department of Biochemistry All India Institute of Medical Sciences Jodhpur Jodhpur) Rajnish Joshi (Deparment of General Medicine All India Institute of Medical Sciences Bhopal Bhopal) Sudhanshu Shekhar Mishra (Department of Physiology All India Institute of Medical Sciences Bhopal Bhopal) Rajay N Bharshankar (Department of Physiology All India Institute of Medical Sciences Bhopal Bhopal) Sunita Tiwari (Department of Physiology King George’s Medical University Lucknow) Pankaj Kumar Singh (Department of Biochemistry All India Institute of Medical Sciences Bibinagar Bibinagar) Vivek Vidyadhar Bhosale (Toxicology and Experimental Medicine Division CSIR-Central Drug Research Institute Lucknow India) Mahendra Pal Singh Negi (Toxicology and Experimental Medicine Division CSIR-Central Drug Research Institute Lucknow India)
저널정보
대한비만학회 Journal of Obesity & Metabolic Syndrome Journal of Obesity & Metabolic Syndrome Vol.30 No.3
발행연도
2021.9
수록면
304 - 311 (8page)
DOI
https://doi.org/10.7570/jomes20131

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Background: It is well established that obesity is a major health risk in diabetes and associated diseases. Epigenetic changes, specially DNA methylation, play an important role in regulation of adipokines. The objective of the present study was to evaluate the DNA methylation status at the promoter region of the leptin gene in obese individuals and its association with metabolic risk factors. Methods: The study included obese (n=100) and non-obese (n=75) individuals aged 25?45 years, and measured their physical, biochemical parameters (glucose, insulin, and lipid profiles) and leptin, DNA methyltransferase 1 (DNMT1), and DNA methyltransferase 3 beta (DNMT3b) mRNA expressions with real-time reverse transcription-polymerase chain reaction (qRT-PCR). DNA methylation of the leptin gene at the promoter region was analyzed by methyl-specific qPCR . Results: The study found that the DNA methylation level at the promoter area of the leptin gene was negatively associated with weight in obese subjects. Furthermore, study findings showed that the DNA methylation level was negatively associated with fasting insulin, glucose, homeostatic model assessment for insulin resistance, and total cholesterol. There was also a higher expression of DNMT1 and DNMT-3b in obese subjects as compared with non-obese subjects. Conclusion: The leptin epigenetic profile may be associated with obesity and its associated metabolic risk factors.
#DNA methylation #DNA methyltransferase #Leptin #Obesity

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참고문헌 (34)

참고문헌 신청
Ogden CL / 2012 / Prevalence of obesity and trends in body mass index among US children and adolescents, 1999-2010 / JAMA 307:483~490 google schola O’Rahilly S / 2009 / Human genetics illuminates the paths to metabolic disease / Nature 462:307~314 google schola Rosen ED / 2006 / Adipocytes as regulators of energy balance and glucose homeostasis / Nature 444:847~853 google schola Pi-Sunyer X / 2009 / The medical risks of obesity / Postgrad Med 121:21~33 google schola World Health Organization / 2016 / World health report 2012 fact sheet 311 google schola

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