DNMT3B -149 C>T and -579 G>T Polymorphisms and Risk of Gastric and Colorectal Cancer: a Meta-analysis

Khoram-Abadi, Khadijeh Mirzaee; Forat-Yazdi, Mohammad; Kheirandish, Shahnaz; Saeidi, Nasim; Zarezade, Zeinab; Mehrabi, Nahid; Neamatzadeh, Hossein

추천

검색

자료유형: 학술저널

저자정보: Khoram-Abadi, Khadijeh Mirzaee (Department of Anatomy, Internationl Campus, Shahid Sadoughi University of Medical Sciences) Forat-Yazdi, Mohammad (Department of Internal Medicine, Internationl Campus, Shahid Sadoughi University of Medical Sciences) Kheirandish, Shahnaz (Department of Internal Medicine, Internationl Campus, Shahid Sadoughi University of Medical Sciences) Saeidi, Nasim (Department of Internal Medicine, Internationl Campus, Shahid Sadoughi University of Medical Sciences) Zarezade, Zeinab (Department of Internal Medicine, Internationl Campus, Shahid Sadoughi University of Medical Sciences) Mehrabi, Nahid (Department of Biology, Science Faculty, University of Yazd) Neamatzadeh, Hossein (Department of Medical Genetics, Internationl Campus, Shahid Sadoughi University of Medical Sciences)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제17권 제6호

발행연도: 2016.1

수록면: 3,015 - 3,020 (6page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Background: Numerous studies have investigated associations of DNA methyltransferase (DNMT) -149 C>T and -579 G>T polymorphisms with gastric cancer (GC) and colorectal cancer (CRC) susceptibility; however, the findings are inconsistent prompting the present meta-analysis. Materials and Methods: Related studies were identified from PubMed, Google scholar, and SID until 10 October 2015. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of the associations. Results: Eleven studies were included based on the search criteria for CRC and GC related to the DNMT3B 149 C>T (3,353 cases and 4,936 controls) and DNMT3B 579 G>T (1,387 cases and 2,064 controls) polymorphisms. There was no significant association overall between DNMT3B -149 and 579 polymorphisms and the risk of cancer. In the stratified analysis by cancer type, DNMT3B 579G>T polymorphism was associated with the risk of CRC and GC. While the DNMT3B -149C/T polymorphism was related with a significantly increased risk of CRC in two tested models, dominant (GG+GT vs. TT: OR 0.51, 95 % CI 0.38-0.69; P = 0.00, Pheterogeneity=0.69, $I^2=0%$) and heterozygote (GT vs. TT: OR 0.50, 95 % CI 0.37-0.69; P=0.00, Pheterogeneity=0.41, $I^2=0%$), no evidence of any association with GC risk was observed as in the pooled analyses. Conclusions: More studies are needed to assess associations of DNMT3B -149C/T and DNMT3B 579G>T polymorphisms with cancer in different ethnicities with large population sizes to generate comprehensive conclusions.

#DNA methyltransferases #CRC #gastric cancer #polymorphism

참고문헌 (0)

참고문헌 신청

참고문헌이 DBpia에서 서비스 중이라면, [참고문헌 신청]을 통해 등록해보세요

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!