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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 464 - 472 (9page)
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Purpose This study was conducted to investigate the role of four polymorphic variants of DNA methyltransferase genes as risk factors for radiation-induced fibrosis in breast cancer patients.
We also assessed their ability to improve prediction accuracy when combined with mitochondrial haplogroup H, which we previously found to be independently associated with a lower hazard of radiation-induced fibrosis.
Materials and Methods DNMT1 rs2228611, DNMT3A rs1550117, DNMT3A rs7581217, and DNMT3B rs2424908 were genotyped by real-time polymerase chain reaction in 286 Italian breast cancer patients who received radiotherapy after breast conserving surgery. Subcutaneous fibrosis was scored according to the Late Effects of Normal Tissue–Subjective Objective Management Analytical (LENT-SOMA) scale. The discriminative accuracy of genetic models was assessed by the area under the receiver operating characteristic curves (AUC).
Results Kaplan-Meier curves showed significant differences among DNMT1 rs2228611 genotypes in the cumulative incidence of grade 2 subcutaneous fibrosis (log-rank test p-value= 0.018). Multivariate Cox regression analysis revealed DNMT1 rs2228611 as an independent protective factor for moderate to severe radiation-induced fibrosis (GG vs. AA; hazard ratio, 0.26; 95% confidence interval [CI], 0.10 to 0.71; p=0.009). Adding DNMT1 rs2228611 to haplogroup H increased the discrimination accuracy (AUC) of the model from 0.595 (95% CI, 0.536 to 0.653) to 0.655 (95% CI, 0.597 to 0.710).
Conclusion DNMT1 rs2228611 may represent a determinant of radiation-induced fibrosis in breast cancer patients with promise for clinical usefulness in genetic-based predictive models.
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참고문헌 (29)
참고문헌 신청
Duan F / 2015 / Systematic evaluation of cancer risk associated with DNMT3B polymorphisms / J Cancer Res Clin Oncol 141:1205~1220
Mostowska A / 2013 / DNMT1, DNMT3A and DNMT3B gene variants in relation to ovarian cancer risk in the Polish population / Mol Biol Rep 40:4893~4899
Hossain MB / 2012 / Low-level environmental cadmium exposure is associated with DNA hypomethylation in Argentinean women / Environ Health Perspect 120:879~884
Martinez-Redondo D / 2010 / Human mitochondrial haplogroup H: the highest VO2max consumer: is it a paradox / Mitochondrion 10:102~107
Zhang QQ / 2014 / TET3mediates the activation of human hepatic stellate cells via modulating the expression of long non-coding RNA HIF1AAS1 / Int J Clin Exp Pathol 7:7744~7751
Mostowska A / 2013 / DNMT1, DNMT3A and DNMT3B gene variants in relation to ovarian cancer risk in the Polish population / Mol Biol Rep 40:4893~4899
Hossain MB / 2012 / Low-level environmental cadmium exposure is associated with DNA hypomethylation in Argentinean women / Environ Health Perspect 120:879~884
Martinez-Redondo D / 2010 / Human mitochondrial haplogroup H: the highest VO2max consumer: is it a paradox / Mitochondrion 10:102~107
Zhang QQ / 2014 / TET3mediates the activation of human hepatic stellate cells via modulating the expression of long non-coding RNA HIF1AAS1 / Int J Clin Exp Pathol 7:7744~7751
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