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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 1,053 - 1,059 (7page)
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The germline c3 transcripts (GLTc3) is transcribed by mouse B cells following stimulation with lipopolysaccharide (LPS). GLTc3 transcription is a prerequisite for IgG3 class switching. However, to date, the promoter activity of GLTc3 has not been investigated. In this study, we constructed GLTc3 promoter reporters and tested their promoter activities following LPS stimulation in B cells. Among the reporters, pGL3-c3(F4) had the highest basal activity and was optimally activated by LPS. Deletion of the first and second conserved sequences (CS1 and CS2) in the GLTc3 promoter abrogated LPS-induced promoter activity. In addition, DNase I-hypersensitive site 1,2 (HS1,2) further enhanced GLTc3 promoter activity. These findings indicate that CS1 and CS2 of the GLTc3 promoter are essential for LPS-induced GLTc3 transcription and that HS1,2 enhances transcription.
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참고문헌 (35)
참고문헌 신청
Birshtein BK / 1997 / Murine and human 30IgH regulatory sequences / Curr Top Microbiol Immunol 224:73~80
Cogne M / 1994 / A class switch control region at the 30 end of the immunoglobulin heavy chain locus / Cell 77:737~747
Collins JT / 1993 / Germline transcripts of the murine immunoglobulin gamma 2a gene: structure and induction by IFN-gamma / Int Immunol 5:885~891
Delphin S / 1995 / Characterization of an interleukin 4 (IL-4) responsive region in the immunoglobulin heavy chain germline epsilon promoter: regulation by NF-IL-4, a C/EBP family member and NF-j B/p50 / J Exp Med 181:181~192
Dunnick WA / 2005 / The 30 end of the heavy chain constant region locus enhances germline transcription and switch recombination of the four gamma genes / J Exp Med 201:1459~1466
Cogne M / 1994 / A class switch control region at the 30 end of the immunoglobulin heavy chain locus / Cell 77:737~747
Collins JT / 1993 / Germline transcripts of the murine immunoglobulin gamma 2a gene: structure and induction by IFN-gamma / Int Immunol 5:885~891
Delphin S / 1995 / Characterization of an interleukin 4 (IL-4) responsive region in the immunoglobulin heavy chain germline epsilon promoter: regulation by NF-IL-4, a C/EBP family member and NF-j B/p50 / J Exp Med 181:181~192
Dunnick WA / 2005 / The 30 end of the heavy chain constant region locus enhances germline transcription and switch recombination of the four gamma genes / J Exp Med 201:1459~1466
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