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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 611 - 617 (7page)
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초록· 키워드
오류제보하기
Extracellular matrix (ECM) molecules are essential structural components that exhibit important functional roles in the control of key cellular events, including cell adhesion, migration, proliferation, differentiation, and survival. The ECM remodeling pathway is also important for tumorigenesis and the metastatic progression of cancer. In this study, we determined the methylation pattern of nineteen ECM genes in colon cancer cell lines and demonstrated that these genes were frequently hypermethylated in primary colon tissues. Upon extracting gene expression profile data of the mouse epithelium and mesenchymal compartments, we found that several ECM genes (CD109, EVL, FBN2, FLNC, IGFBP3, MMP2, and LAMA1) were highly expressed in the mesenchymal compartment. These results were confirmed via reverse transcription polymerase chain reaction analysis. Moreover, we demonstrated the correlation between transcriptional silencing and the promoter hypermethylation of LAMA1, FBN2, and IGFBP3 during the transformation of the mesenchymal stem cell model system using key genetic alterations that develop during human malignance. Interestingly, MMP2, IGFBP3, and LAMA1 mRNA levels were significantly decreased during the transformation. In terms of transcriptional silencing by promoter DNA hypermethylation, the lack of LAMA1 mRNA expression was associated with its promoter hypermethylation in the last step of transformation, which develops to malignancies. Overall, our data suggest that ECM alterations by hypermethylated genes may contribute to carcinogenesis through the silencing of ECM pathway genes by epigenetic alterations.
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등록된 정보가 없습니다.
참고문헌 (32)
참고문헌 신청
Bateman JF / 2009 / Genetic diseases of connective tissues: cellular and extracellular effects of ECM mutations / Nat Rev Genet 10:173~183
Bernstein BE / 2007 / The mammalian epigenome / Cell 128:669~681
Bjerkvig R / 2005 / Opinion: the origin of the cancer stem cell: current controversies and new insights / Nat Rev Cancer 5:899~904
Bonnans C / 2014 / Remodelling the extracellular matrix in development and disease / Nat Rev Mol Cell Biol 15:786~801
Calon A / 2015 / Stromal gene expression defines poor-prognosis subtypes in colorectal cancer / Nat Genet 47:320~329
Bernstein BE / 2007 / The mammalian epigenome / Cell 128:669~681
Bjerkvig R / 2005 / Opinion: the origin of the cancer stem cell: current controversies and new insights / Nat Rev Cancer 5:899~904
Bonnans C / 2014 / Remodelling the extracellular matrix in development and disease / Nat Rev Mol Cell Biol 15:786~801
Calon A / 2015 / Stromal gene expression defines poor-prognosis subtypes in colorectal cancer / Nat Genet 47:320~329
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