지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology Vol.34 No.8
- 발행연도
- 2024.8
- 수록면
- 1,711 - 1,717 (7page)
- DOI
- 10.4014/jmb.2405.05036
이용수
초록· 키워드
오류제보하기
This study evaluates the efficacy of a decellularized intestine tissue-derived extracellular matrix (Intestine ECM) as a scaffold for culturing colorectal cancer (CRC) organoids and establishing cellderived xenograft (CDX) models, comparing its performance to traditional Matrigel. Intestine ECM demonstrates comparable support for organoid formation and cellular function, highlighting its potential as a more physiologically relevant and reproducible platform. Our findings suggest that Intestine ECM enhances the mimetic environment for colon epithelium, supporting comparable growth and improved differentiation compared to Matrigel. Moreover, when used as a delivery carrier, Intestine ECM significantly increases the growth rate of CDX models using patient-derived primary colorectal cancer cells. This enhancement demonstrates Intestine ECM’s role not only as a scaffold but also as a vital component of the tumor microenvironment, facilitating more robust tumorigenesis. These findings advocate for the broader application of Intestine ECM in cancer model systems, potentially leading to more accurate preclinical evaluations and the development of targeted cancer therapies.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Comparison of the Genetic Alterations between Primary Colorectal Cancers and Their Corresponding Patient-Derived Xenograft Tissues
Genomics & informatics
2018 .01
-
Anti-cancer Role of Probiotic-derived P8 Protein in Colorectal Cancer
한국미생물학회 학술대회논문집
2022 .10
-
Microbiota is Associated with Anti-stress in the Intestine and Brain
한국미생물학회 학술대회논문집
2020 .10
-
Microbiota is Associated with Anti-stress in the Intestine and Brain
한국미생물학회 학술대회논문집
2021 .08
-
Microbiome Regulate the Depression in the Intestine and Brain
한국미생물학회 학술대회논문집
2021 .08
-
DNA methylation changes in extracellular remodeling pathway genes during the transformation of human mesenchymal stem cells
Genes & Genomics
2016 .01
-
Molecular fossils “pseudogenes” as functional signature in biological system
Genes & Genomics
2020 .01
-
An Integrative Approach to Precision Cancer Medicine Using Patient-Derived Xenografts
Molecules and Cells
2016 .02
-
Development of Wound Dressing based on Fish Acellular Matrix
한국해양바이오학회지
2024 .12
-
Induction of Cell Death by Bifidobacterium infantis DS1685 in Colorectal and Breast Cancers via SMAD4/TGF-Beta Activation
Journal of Microbiology and Biotechnology
2024 .08
-
Commensal-derived Metabolites Govern Vibrio cholerae Pathogenesis in Host Intestine
한국미생물학회 학술대회논문집
2019 .04
-
Adhesion Activity of Lactobacillus plantarum PM 008 Isolated from Kimchi on the Intestine of Mice
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2022 .06
-
Novel Psychrophilic Bacteria Isolated from Intestine and Stomach of Marine Shrimps
한국미생물학회 학술대회논문집
2022 .10
-
β-carotene regulates cancer stemness in colon cancer in vivo and in vitro
Nutrition Research and Practice
2022 .04
-
β-carotene regulates cancer stemness in colon cancer in vivo and in vitro
Nutrition Research and Practice
2022 .04
-
Mineralized Polysaccharide Transplantation Modules Supporting Human MSC Conversion into Osteogenic Cells and Osteoid Tissue in a Non-Union Defect
Molecules and Cells
2018 .12
-
Long non-coding RNA H19X promotes tumorigenesis and metastasis of colorectal cancer through regulating the miR-503-5p/KANK1 axis
Genes & Genomics
2022 .12
-
The Microbiome-Immune Axis Therapeutic Effects in Cancer Treatments
Journal of Microbiology and Biotechnology
2022 .09
-
Metabolomic analysis of organic acids and fatty acids in plasma and organs from HCT116 xenograft mouse model
한국분석과학회 학술대회
2023 .05
최근 본 자료
댓글(0)
0