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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 509 - 518 (10page)
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In this study, digital gene expression (DGE)sequencing technology was used to identify alterations ingene transcription of the ovarian tissue of Chlamys farreri(C. farreri) exposed to benzo[a]pyrene (BaP) pollutants. Atotal of 124 genes were detected differentially expressed with 42 up-regulated and 82 down-regulated genes in BaP DGE libraries. Gene ontology annotation and kyoto encyclopedia of genes and genomes pathway analyses were performed on all genes to elucidate their biological functions and processes. The results showed that numerous enriched differentially expressed genes related to ‘‘detoxification process’’, ‘‘damage effects to extracellular matrix and cell interactions’’, ‘‘endocrine disrupting effects’’ and ‘‘tissue damage responses’’. Quantitative RT-PCR procedure was executed to understand the expression patterns of several important reproductive-related genes. To supplement the reproductive toxicity of BaP, histological analysis of the ovaries illustrated that after 21 days higher dose of BaP exposure, the immature oocytes and degenerated oocytes increased. The study aims to provide reference data for future study of organic pollutions in aquatic mollusks.
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참고문헌 (56)
참고문헌 신청
An KW / 2008 / Physiological responses and expression of metallothionein (MT) and superoxide dismutase (SOD) mRNAs in olive flounder, Paralichthys olivaceus exposed to benzo[a]pyrene / Comp Biochem Physiol B Biochem Mol Biol 149:534~539
Andrews GK / 2000 / Regulation of metallothionein gene expression by oxidative stress and metal ions / Biochem Pharmacol 59:95~104
Bemanian V / 2004 / The aryl hydrocarbon receptor-mediated disruption of vitellogenin synthesis in the fish liver: cross-talk between AhR- and ER alpha-signalling pathways / Comp Hepatol 3:1~14
Benjamini Y / 1995 / Controling the false discovery rate: a practical and powerful approach to multiple testing / J Roy Stat Soc B 57:289~300
Cangialosi MV / 2010 / Screening of ovarian steroido-genic pathway in Ciona intestinalis and its modulation after tributyltin exposure / Toxicol Appl Pharmacol 245:124~133
Andrews GK / 2000 / Regulation of metallothionein gene expression by oxidative stress and metal ions / Biochem Pharmacol 59:95~104
Bemanian V / 2004 / The aryl hydrocarbon receptor-mediated disruption of vitellogenin synthesis in the fish liver: cross-talk between AhR- and ER alpha-signalling pathways / Comp Hepatol 3:1~14
Benjamini Y / 1995 / Controling the false discovery rate: a practical and powerful approach to multiple testing / J Roy Stat Soc B 57:289~300
Cangialosi MV / 2010 / Screening of ovarian steroido-genic pathway in Ciona intestinalis and its modulation after tributyltin exposure / Toxicol Appl Pharmacol 245:124~133
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