지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.8
- 수록면
- 558 - 566 (9page)
이용수
초록· 키워드
오류제보하기
Regular monitoring on experimental animal management found the fluctuation of ART outcome, which showed a necessity to explore whether superovulation treatment is responsible for such unexpected outcome. This study was subsequently conducted to examine whether su-perovulation treatment can preserve ultrastructural integrity and developmental competence of oocytes following oocyte activation and embryo culture. A randomized study using mouse model was designed and in vitro development (experiment 1), ultrastructural morphology (experiment 2) and functional integrity of the oocytes (experiment 3) retrieved after PMSG/hCG in-jection (superovulation group) or not (natural ovulation; control group) were evaluated. In experiment 1, more oocytes were retrieved following superovulation than following natural ovulation, but natural ovulation yielded higher (p < 0.0563) maturation rate than superovulation. The capacity of mature oocytes to form pronucleus and to develop into blastocysts in vitro was similar. In experiment 2, a notable (p < 0.0186) increase in mitochondrial deformity, characterized by the formation of vacuolated mitochondria, was detected in the superovulation group. Multivesicular body formation was also increased, whereas early endosome formation was significantly decreased. No obvious changes in other microorganelles, however, were detected, which included the formation and distribution of mitochondria, cortical granules, microvilli, and smooth and rough endoplasmic reticulum. In experiment 3, significant decreases in mitochondrial activity, ATP production and dextran uptake were detected in the superovulation group. In conclusion, superovulation treatment may change both maturational status and functional and ultrastuctural integrity of oocytes. Superovulation effect on preimplantation development can be discussed.
목차
등록된 정보가 없습니다.
참고문헌 (54)
참고문헌 신청
Assey, R. J. / 1994 / Oocyte structure and follicular steroid concentrations in superovulated versus unstimulated heifers / Mol. Reprod. Dev 39:8~16
Baart, E. B. / 2007 / Milder ovarian stimulation for in-vitro fertilization reduces aneuploidy in the human preimplantation embryo: a randomized controlled trial / Hum. Reprod 22:980~988
Balaban, R. S. / 2005 / Mitochondria, oxidants, and aging / Cell 120:483~495
Beaumont, H. M. / 1975 / Embryonic mortality during the pre- and post-implantation periods of pregnancy in mature mice after superovulation / J. Reprod. Fertil 45:437~448
Burdette, J. E. / 2006 / Gonadotropin-induced superovulation drives ovarian surface epithelia proliferation in CD1 mice / Endocrinology 147:2338~2345
Baart, E. B. / 2007 / Milder ovarian stimulation for in-vitro fertilization reduces aneuploidy in the human preimplantation embryo: a randomized controlled trial / Hum. Reprod 22:980~988
Balaban, R. S. / 2005 / Mitochondria, oxidants, and aging / Cell 120:483~495
Beaumont, H. M. / 1975 / Embryonic mortality during the pre- and post-implantation periods of pregnancy in mature mice after superovulation / J. Reprod. Fertil 45:437~448
Burdette, J. E. / 2006 / Gonadotropin-induced superovulation drives ovarian surface epithelia proliferation in CD1 mice / Endocrinology 147:2338~2345
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