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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 263 - 274 (12page)
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Chlamys farreri (C. farreri), as an economic species of marine bivalves, can tolerate manifold anthropogenic stressors including persistent organic pollutants (POPs) stress. A systematic study of transcriptome after POPs exposure may provide insights into the mechanism of acquired pollution tolerance. In this study, we compared C. farreri transcriptome by reanalyzing DGE (digital gene expression) data from previous study. Our results revealed a toxicant-dependent pattern of global transcriptional responses, with 108, 126 and 138 DEGs regulated by BaP, TBBPA and PAHs cocktail (mixed by benzo(a)pyrene, benz(a)anthracene, benzo(b)fluoranthene and chrysene with the ratio of 5:3:1:1) exposure, respectively. Among these DEGs, 219 were commonly regulated by all pollutants, whereas the minority of differences were conditionspecific. In addition, we performed the first hierarchical cluster analysis of the common transcripts throughout three types of contaminants stress ulteriorly, leading to new discoveries of genes’ association information with dynamical gene expression data of C. farreri, which goes beyond the focus on individuals. It revealed a cascade of gene expression patterns in the response of C. farreri to different environmental stresses and may be beneficial for further analysis of novel environmental metrics.
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참고문헌 (60)
참고문헌 신청
Ames B / 2013 / Tetrabrominated bisphenol A inhibition studies on six cytochrome P450 enzymes in human liver microsomes
An J / 2014 / Hexabromocyclododecane and polychlorinated biphenyls increase resistance of hepatocellular carcinoma cells to cisplatin through the phosphatidylinositol 3-kinase/protein kinase B pathway / Toxicol Lett 229:265~272
Anzenbacher P / 2001 / Cytochromes P450 and metabolism of xenobiotics / Cell Mol Life Sci 58:737~747
Baba Y / 2008 / The Expression of type IV collagen a6 chain is related to the prognosis in patients with esophageal squamous cell carcinoma / Ann Surg Oncol 15:555~565
Batore´u MCC / 2005 / Risk of human exposure to paralytic toxins of algal origin / Environ Toxicol Pharmacol 19:401~406
An J / 2014 / Hexabromocyclododecane and polychlorinated biphenyls increase resistance of hepatocellular carcinoma cells to cisplatin through the phosphatidylinositol 3-kinase/protein kinase B pathway / Toxicol Lett 229:265~272
Anzenbacher P / 2001 / Cytochromes P450 and metabolism of xenobiotics / Cell Mol Life Sci 58:737~747
Baba Y / 2008 / The Expression of type IV collagen a6 chain is related to the prognosis in patients with esophageal squamous cell carcinoma / Ann Surg Oncol 15:555~565
Batore´u MCC / 2005 / Risk of human exposure to paralytic toxins of algal origin / Environ Toxicol Pharmacol 19:401~406
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