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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 439 - 445 (7page)
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Chlamys farreri is an important economic mollusk and is able to accumulate cadmium (Cd) excessively. Two cDNA libraries from gill of C. farreri which were Cd treated or not were generated based on the Illumina sequencing platform in order to identify differentially expressed genes (DEGs) associated with cadmium accumulation. The analysis of comparative transcriptomics identified 82,800 unigenes and 128 differentially expressed genes. Of these, 8 of the most significant DEGs were verified by real-time PCR, showing consistent trends in expression patterns between the two techniques. KEGG pathways analysis revealed that 37 associated processes were highly enriched. A set of key DEGs were identified that may play important roles in cadmium exposure. Our work presents an overview of gene expression change during cadmium exposure to C. farreri and identifies a series of candidate genes and pathways for further research on the molecular mechanisms of cadmium accumulation.
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참고문헌 (33)
참고문헌 신청
Audic S / 1997 / The significance of digital gene expression profiles / Genome Res 7:986~995
Company R / 2006 / Temporal variation in the antioxidant defence system and lipid peroxidation in the gills and mantle of hydrothermal vent mussel Bathymodiolus azoricus / Deep-Sea Res Part I 53:1101~1116
Faria M / 2009 / Multi-biomarker responses in the freshwater mussel Dreissena polymorpha exposed to polychlorobiphenyls and metals / Comp Biochem Physiol C 149:281~288
Ferguson LC / 2011 / Evolution of the insect yellow gene family / Mol Biol Evol 28:257~272
Fleury E / 2010 / Microarray based identification of gonad transcripts differentially expressed between lines of Pacific oyster selected to be resistant or susceptible to summer mortality / Mar Biotechnol 12:326~329
Company R / 2006 / Temporal variation in the antioxidant defence system and lipid peroxidation in the gills and mantle of hydrothermal vent mussel Bathymodiolus azoricus / Deep-Sea Res Part I 53:1101~1116
Faria M / 2009 / Multi-biomarker responses in the freshwater mussel Dreissena polymorpha exposed to polychlorobiphenyls and metals / Comp Biochem Physiol C 149:281~288
Ferguson LC / 2011 / Evolution of the insect yellow gene family / Mol Biol Evol 28:257~272
Fleury E / 2010 / Microarray based identification of gonad transcripts differentially expressed between lines of Pacific oyster selected to be resistant or susceptible to summer mortality / Mar Biotechnol 12:326~329
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