지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 1,451 - 1,459 (9page)
이용수
초록· 키워드
오류제보하기
The purpose of the present study was to find novel loci associated with hyperuricemia using data from a genome-wide association study (GWAS) conducted on healthy Koreans. We conducted a GWAS using data from a community-based cohort study where 3,647 subjects aged 40–89 were recruited by the Korea National Institute of Health (KNIH). The community-based cohort consisted of subjects who did not suffer from any of 6 major diseases (hypertension, hyperlipidemia, diabetes, heart diseases, brain diseases, and cancers). Epidemiologic information includes 249 traits such as epidemiological surveys, physical examinations, and laboratory tests. A total of 3,647 participants, including 234 hyperuricemia cases (serum uric acid [SUA] level was 7 mg/dL or higher) and 3,413 controls, were genotyped by Illumina HumanOmni1-Quad BeadChip GWAS array at KNIH. In the multivariate regression analysis of clinical variables, significant variables associated with hyperuricemia were male gender (odds ratio [OR], 5.526; P = 3.2 × 10−10), old age (OR, 1.017; P = 0.040), high body mass index (BMI) (OR, 1.147; P = 5.4 × 10−7), current alcohol intake (OR, 2.413; P = 4.7 × 10−7), and high creatinine (OR, 1.647; P = 1.6 × 10−13). We identified a hyperuricemia susceptible loci (rs2054576 in ABCG2, OR, 1.883; P = 4.7 × 10−8) that passed a genome-wide significance threshold, adjusted by clinical variables (male, age, BMI, current alcohol, and creatinine). It was first identified that rs2054576 in ABCG2 is associated with hyperuricemia. Our results should be validated through replication studies among other Korean subjects or various ethnic groups.
목차
등록된 정보가 없습니다.
참고문헌 (40)
참고문헌 신청
So A / 2010 / Uric acid transport and disease / J Clin Invest 120:1791~1799
Anzai N / 2012 / Recent advances in renal urate transport : characterization of candidate transporters indicated by genome-wide association studies / Clin Exp Nephrol 16:89~95
Köttgen A / 2013 / Genome-wide association analyses identify 18 new loci associated with serum urate concentrations / Nat Genet 45:145~154
Kolz M / 2009 / Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations / PLoS Genet 5:e1000504
Lee YH / 2012 / Pathway analysis of genome-wide association studies on uric acid concentrations / Hum Immunol 73:805~810
Anzai N / 2012 / Recent advances in renal urate transport : characterization of candidate transporters indicated by genome-wide association studies / Clin Exp Nephrol 16:89~95
Köttgen A / 2013 / Genome-wide association analyses identify 18 new loci associated with serum urate concentrations / Nat Genet 45:145~154
Kolz M / 2009 / Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations / PLoS Genet 5:e1000504
Lee YH / 2012 / Pathway analysis of genome-wide association studies on uric acid concentrations / Hum Immunol 73:805~810
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Prevalence of hyperuricemia and its association with metabolic syndrome and cardiometabolic risk factors in Korean children and adolescents: analysis based on the 2016-2017 Korea National Health and Nutrition Examination Survey
Korean journal of pediatrics
2019 .01
-
Mechanisms Linking Hyperuricemia to Increased Cardiovascular Risk
Journal of Korean Medical Science
2019 .01
-
Hyperuricemia is Associated With an Increased Prevalence of Metabolic Syndrome in a General Population and a Decreased Prevalence of Diabetes in Men
대한류마티스학회지
2020 .01
-
양평 중년 성인의 상대 악력, 상대 각력과 고요산혈증 간의 연관성
대한스포츠의학회지
2018 .01
-
Hyperuricemia Is Not Predictive of Long- Term Outcome in Patients with Stable Chronic Obstructive Pulmonary Disease
Journal of Korean Medical Science
2020 .01
-
Rising a Novel Weapon in the War against Gout and Hyperuricemia
대한류마티스학회지
2016 .01
-
한국 성인의 고요산혈증과 건강 관련 삶의 질과의 연관성: 제7기 국민건강영양조사 자료 이용(2016–2017년)
Korean Journal of Family Practice
2019 .01
-
Synergistic Interaction between Hyperuricemia and Abdominal Obesity as a Risk Factor for Metabolic Syndrome Components in Korean Population
Diabetes and Metabolism Journal
2022 .09
-
Hyper-homocysteinemia Inducing Hyperuricemia: What are the Mechanisms?
대한류마티스학회지
2017 .01
-
Putative Pathogenic Variants of ABCG5 and ABCG8 of Sitosterolemia in Patients With Hyper-Low-Density Lipoprotein Cholesterolemia
지질·동맥경화학회지
2024 .01
-
한국 성인에서의 고요산혈증 유병률과 비만과의 관계: 제7기 국민건강영양 자료(2018)
Korean Journal of Family Practice
2020 .01
-
중년 성인의 무증상 고요산혈증과 대사성 비만 표현형 간의 연관성
한국보건기초의학회지
2023 .06
-
Hyperuricemia is a risk factor for the progression to end-stage renal disease in minimal change disease
Kidney Research and Clinical Practice
2021 .09
-
J-shaped Relationship Between Chronic Kidney Disease and Serum Uric Acid Levels: A Cross-sectional Study on the Korean Population
대한류마티스학회지
2021 .10
-
Is the Serum Uric Acid Level Independently Associated with Incidental Urolithiasis?
대한류마티스학회지
2018 .01
-
한국 성인에서 좌식시간과 고요산혈증 간의 연관성: 제7기(2016–2018년) 국민건강영양조사 자료 바탕으로
Korean Journal of Family Practice
2020 .01
-
Hyperuricemia and Urologic Disease
Urogenital Tract Infection
2017 .01
-
한국 성인의 수면시간과 혈중 요산 농도와의 연관성: 2016? 2018년 국민건강영양조사 자료 분석 결과
Korean Journal of Family Practice
2021 .12
-
한국 40대 이상 성인에서 목둘레 길이와 고요산혈증 간의 연관성: 2019 국민건강영양조사 제8기 자료를 바탕으로
Korean Journal of Family Practice
2023 .03
-
Validation of age- and sex-dependent association of uric acid and incident hypertension in rural areas
Clinical Hypertension
2022 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0