Hyperuricemia Is Not Predictive of Long- Term Outcome in Patients with Stable Chronic Obstructive Pulmonary Disease

황재준; 오연목; Chin Kook Rhee; 유광하; 박용범; Ho Il Yoon; 임성용; Ji-Hyun Lee; 김은경; Tae Hyung Kim; Sei Won Lee; Sang Do Lee; 이재승; KOLD Group

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저자정보: 황재준 (강동경희대학교병원) 오연목 (서울아산병원) Chin Kook Rhee (Department of Internal Medicine College of Medicine Seoul St. Mary’s Hospital The Catholic Universi) 유광하 (건국대학교) 박용범 (한림대학교 강동성심병원) Ho Il Yoon (Department of Internal Medicine Seoul National University College of Medicine) 임성용 (성균관대학교) Ji-Hyun Lee (CHA University College of Medicine) 김은경 (차의과학대학교 분당차병원 호흡기알레르기내과) Tae Hyung Kim (Hanyang University) Sei Won Lee (Department of Pulmonary and Critical Care Medicine Clinical Research Center for Chronic Obstructive) Sang Do Lee (Department of Pulmonary and Critical Care Medicine Clinical Research Center for Chronic Obstructive) 이재승 (울산대학교) KOLD Group (KOLD Group)

저널정보: 대한의학회 Journal of Korean Medical Science Journal of Korean Medical Science Vol.35 No.8

발행연도: 2020.1

수록면: 1 - 9 (9page)

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Background: Although the association of hyperuricemia with an increased risk of mortality has been demonstrated in the context of acute exacerbation of chronic obstructive pulmonary disease (COPD), the long-term outcomes of hyperuricemia have not been studied in the case of stable COPD. Methods: We retrospectively analyzed baseline data of 240 men with stable COPD enrolled in the Korea Obstructive Lung Disease cohort. We evaluated associations between serum uric acid levels and clinical parameters, risk factors for all-cause mortality, and acute exacerbation of COPD. Results: The mean age of subjects was 66.4 ± 7.7 years, and the median follow-up time was 5.9 years. We identified no significant difference in terms of lung function or laboratory findings between patients with hyperuricemia and those without. Serum uric acid level was negatively associated with systemic inflammation indicated by neutrophil–lymphocyte ratio (r = −0.211, P = 0.001). Univariate Cox regression analysis revealed hyperuricemia to not be associated with an increased risk of all-cause mortality in men with stable COPD (hazard ratio [HR], 0.580; 95% confidence interval [CI], 0.250–1.370; P = 0.213). In the multivariate Cox regression model, hyperuricemia was not an independent predictor of acute exacerbation (HR, 1.383; 95% CI, 0.977–1.959; P = 0.068). Conclusion: Among men with stable COPD, hyperuricemia is not an independent predictor of all-cause mortality or future acute exacerbation of COPD. These results differ from those of previous studies on patients with acute exacerbation of COPD.

#Hyperuricemia #Chronic Obstructive Pulmonary Disease #Inflammation #Mortality #Acute Exacerbation

참고문헌 (32)

참고문헌 신청

Vestbo J / 2013 / Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease : GOLD executive summary / Am J Respir Crit Care Med 187(4):347~365

박용범 / 2018 / Revised (2018) COPD Clinical Practice Guideline of the Korean Academy of Tuberculosis and Respiratory Disease: A Summary / Tuberculosis and Respiratory Diseases 81(4):261~273

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