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자료유형
학술저널
저자정보
송수현 (전남대학교병원) 오태렴 (전남대학교병원) 최홍상 (전남대학교병원) 김창성 (Chonnam National University Medical School Gwangju Republic of Korea) Ryu Dong-Ryeol (Ewha Womans University) 김성균 (한림대학교) Park Sun-Hee (Kyungpook National University Daegu Republic of Korea) 마성권 (전남대학교) Kim Soo Wan (Chonnam National University) 배은희 (전남대학교) The Korean GlomeruloNEphritis sTudy Group (KoGNET) (The Korean GlomeruloNEphritis sTudy Group (KoGNET))
저널정보
대한신장학회 Kidney Research and Clinical Practice Kidney Research and Clinical Practice Vol.40 No.3
발행연도
2021.9
수록면
411 - 418 (8page)
DOI
10.23876/j.krcp.20.220

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Background: Minimal change disease (MCD) is one of the most common causes of nephrotic syndrome worldwide. Hyperuricemia increases the end-stage renal disease (ESRD) risk in glomerulonephritis. In this study, we aimed to determine the effect of high serum uric acid levels on the progression to ESRD in MCD. Methods: A total of 800 patients diagnosed with MCD by kidney biopsy were retrospectively analyzed. We determined the relation- ship of hyperuricemia with the progression to ESRD in MCD using the Cox proportional hazard model and Kaplan-Meier survival anal- ysis. The primary outcome was defined as the initiation of dialysis or kidney transplantation. Results: A total of 42 patients (5.3%) progressed to ESRD during the follow-up period. In the restricted cubic spline curve, serum uric acid levels exhibited a positive correlation with ESRD progression in patients with MCD. In the fully adjusted model, the risk of MCD progression increased by 29% for every 1 mg/dL increase in the baseline serum uric acid level (hazard ratio [HR], 1.29; 95% confi- dence interval [CI], 1.09?1.54; p = 0.004). Falling into the high uric acid group (serum uric acid level > 7 mg/dL in men and > 6 mg/ dL in women) was also a risk factor for progression of MCD to ESRD (HR, 3.40; 95% CI, 1.59?7.31; p < 0.001). Conclusion: Our study shows that hyperuricemia is an independent risk factor for the progression to ESRD in patients with MCD

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