지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 127 - 130 (4page)
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초록· 키워드
오류제보하기
Hyperuricemia is related to metabolic syndrome, and is defined as an over-production or under-excretion of uric acid (UA), with increased UA serum concentration. Among other causes, Hyper-homocysteinemia (H-Hcy) can be responsible for hyperuricemia. The mechanisms underlying the association between these two conditions are unclear, but increased UA serum levels can be a consequence of renovascular atherosclerosis, with reduced UA excretion. An alternative hypothesis is the overproduction of UA from adenosine (originating from S-adenosyl-homocysteine). Genetic polymorphism (C677T) of methylenetetrahydrofolate reductase (MTHFR) may contribute. A possible mechanism is purines biosyinthesis originating from this gene variant. However, the results obtained from several studies and meta-analyses of the relationship between H-Hcy and hyperuricemia are ambivalent, and broader research is needed.
목차
등록된 정보가 없습니다.
참고문헌 (36)
참고문헌 신청
Richette P / 2010 / Gout / Lancet 375:318~328
Eggebeen AT / 2007 / Gout : an update / Am Fam Physician 76:801~808
Kuzuya M / 2002 / Effect of aging on serum uric acid levels: longitudinal changes in a large Japanese population group / J Gerontol A Biol Sci Med Sci 57:M660~M664
Sumino H / 1999 / Reduction of serum uric acid by hormone replacement therapy in postmenopausal women with hyperuricaemia / Lancet 354:650
Zhu Y / 2011 / Prevalence of gout and hyperuricemia in the US general population : the National Health and Nutrition Examination Survey 2007-2008 / Arthritis Rheum 63:3136~3141
Eggebeen AT / 2007 / Gout : an update / Am Fam Physician 76:801~808
Kuzuya M / 2002 / Effect of aging on serum uric acid levels: longitudinal changes in a large Japanese population group / J Gerontol A Biol Sci Med Sci 57:M660~M664
Sumino H / 1999 / Reduction of serum uric acid by hormone replacement therapy in postmenopausal women with hyperuricaemia / Lancet 354:650
Zhu Y / 2011 / Prevalence of gout and hyperuricemia in the US general population : the National Health and Nutrition Examination Survey 2007-2008 / Arthritis Rheum 63:3136~3141
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