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논문 기본 정보

자료유형
학술저널
저자정보
Doo-Ho Lim (Ulsan University Hospital) Min-ho Kim (Ewha Womans University Mokdong Hospital) Seokchan Hong (Division of Rheumatology Department of Internal Medicine Asan Medical Center University of Ulsan Co) Yong Gil Kim (Department of Internal Medicine University of Ulsan College of Medicine Seoul Korea.) Chang-Keun Lee (Division of Rheumatology Department of Internal Medicine Asan Medical Center University of Ulsan Co) Seung Won Choi (University of Ulsan College of Medicine) Bin Yoo (Asan Medical Center University of Ulsan College of Medicine) Ji Seon Oh (Asan Medical Center University of Ulsan College of Medicine)
저널정보
대한류마티스학회 대한류마티스학회지 대한류마티스학회지 제25권 제2호
발행연도
2018.1
수록면
116 - 121 (6page)

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Objective. Urolithiasis is one of the manifestations of gout and the risk is higher in gouty patients. On the other hand, an independent association between the urinary stone and serum uric acid (UA) level has not been established. This study examined whether the risk of urolithiasis increases with increasing serum UA level. Methods. Among the people who visited a tertiary hospital from 2010 to 2013, 13,964 individuals who underwent both ultrasonography and a laboratory test were recruited in the study. The risk of urolithiasis on ultrasonography was analyzed in association with the serum UA level by multiple logistic regression analysis with an adjustment for age, sex, body mass index, estimated glomerular filtration rate, and known underlying diseases, including diabetes mellitus and hypertension. Results. Among the 6,743 men (48.3%) and 7,221 women (51.7%), the age was 51.3±13.5 and the serum UA level was 4.5±2.1 mg/dL. Hyperuricemia (>7 mg/dL) was observed in 1,381 cases (9.9%). Urolithiasis was detected by ultrasonography in 608 cases (4.4%). The detection rates of urolithiasis in individuals with hyperuricemia and normouricemia were 5.9% and 4.1%, respectively (p=0.001). Multiple logistic regression analysis showed that individuals with hyperuricemia had a significantly higher risk of urolithiasis (adjusted odds ratio [OR]=1.54; 95% confidence interval [CI], 1.20∼1.96; p=0.001). A comparison of the highest with the lowest quartile of serum UA revealed a multivariable-adjusted OR of 3.17 (95% CI, 1.98∼5.11) for men and 1.79 (1.08∼2.93) for women. Conclusion. These results suggest that individuals with a higher serum UA level have a higher risk of subclinical and clinical urolithiasis.

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