Changes in serum uric acid levels after allogeneic hematologic stem cell transplantation: A retrospective cohort study

Sang Hyun Joo; Jin Kyun Park; Eunyoung Emily Lee; Yeong Wook Song; Sung-Soo Yoon

추천

검색

자료유형: 학술저널

저자정보: Sang Hyun Joo (Seoul National University Hospital) Jin Kyun Park (Seoul National University Hospital) Eunyoung Emily Lee (Seoul National University Hospital) Yeong Wook Song (Seoul National University Hospital) Sung-Soo Yoon (Seoul National University Hospital)

저널정보: 대한혈액학회 Blood Research Blood Research Vol.51 No.3

발행연도: 2016.1

수록면: 200 - 203 (4page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

BackgroundSince cell turnover in the hematopoietic system constitutes a major source of uric acid (UA) production, we investigated whether hematopoietic stem cell transplantation (HSCT) is associated with significant changes in serum UA levels in patients with hemato-logical disorders. MethodsPatients who underwent HSCT at our institution between 2001 and 2012 were retro-spectively enrolled. Serum UA levels at 3 months before, 1 week before, and 3 months and 1 year after HSCT were examined. ResultsComplete clinical and laboratory information including data regarding UA levels was avail-able for 93 patients. At baseline, the mean UA level was 4.9±2.1 mg/dL, with an overall prevalence of hyperuricemia of 15% (defined as serum UA>6.8 mg/dL). Mean UA levels tended to be higher in patients with acute myeloid leukemia (4.8±2.0 mg/dL) and non-Hodgkin lymphoma (5.1±2.3 mg/dL) and lower in patients with aplastic anemia (mean, 4.2±1.8 mg/dL). UA levels dropped during myeloablative conditioning, reaching a nadir on the day of HSCT (3.27±1.4 mg/dL). Over the 3 months following HSCT, UA levels rose sharply (5.0±2.1 mg/dL) and remained stable up to 1 year after HSCT (5.5±1.6mg/dL). UA levels in HSCT recipients at 12 months correlated with those of their respective graft donors (Pearson r=0.406, P=0.001).ConclusionHSCT is associated with significant changes in uric acid levels in patients with hematologic disorders.

참고문헌 (10)

참고문헌 신청

Hediger MA / 2005 / Molecular physiology of urate transport / Physiology (Bethesda) 20:125~133

Kamble RT / 2011 / Acute gout at engraftment following hematopoietic transplantation / Am J Hematol 86:961~962

Yamauchi T / 2013 / A high serum uric acid level is associated with poor prognosis in patients with acute myeloid leukemia / Anticancer Res 33:3947~3951

Carpenter PA / 1996 / Late diagnosis and correction of purine nucleoside phosphorylase deficiency with allogeneic bone marrow transplantation / Bone Marrow Transplant 17:121~124

Zegers BJ / 1978 / An approach to the restoration of T cell function in a purine nucleoside phosphorylase deficient patient / Ciba Found Symp 68:231~253

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!