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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Objective. The objective of this study is to assess whether genetic functional variants of disintegrin and metalloprotease 33 (ADAM33) are associated with susceptibility to systemic lupus erythematosus (SLE) in a Korean population. Methods. We previously identified 48 single nucleotide polymorphisms (SNPs) in ADAM33. Six SNPs were selected with regard to the linkage disequilibrium pattern. An association study of ADAM33 was conducted in 190 patients with SLE and 469 control subjects. SNPs were genotyped using the TaqMan Real-time polymerase chain reaction method, and haplotype analyses of related variants were performed. Results. All SNPs were in Hardy-Weinberg equilibrium. Significant associations were found between the ADAM33 polymorphisms and SLE at rs2787094 (adjusted odds ratio [OR] 1.88, 95% confidence interval [CI] 1.00 to 3.54; p＜ 0.0001). The rs554743 polymorphism was associated with the presence of the immunoglobulin M anti-cardiolipin antibody (adjusted OR 0.29, 95% CI 0.10 to 0.83; p=0.021). Conclusion. ADAM33 polymorphisms were associated with susceptibility to SLE and development of clinical disease manifestations in a Korean population. Further study is warranted to clarify the role of ADAM33 in SLE pathogenesis. (J Rheum Dis 2016;23:88-95)
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참고문헌 (33)
참고문헌 신청
Tan EM / 1989 / Antinuclear antibodies: diagnostic markers for autoimmune diseases and probes for cell biology / Adv Immunol 44:93~151
Tsao BP / 2004 / Update on human systemic lupus erythematosus genetics / Curr Opin Rheumatol 16:513~521
Herrmann M / 2000 / Etiopathogenesis of systemic lupus erythematosus / Immunol Today 21:424~426
Gunn TM / 2002 / Identification and preliminary characterization of mouse Adam33 / BMC Genet 3:2
Yoshinaka T / 2002 / Identification and characterization of novel mouse and human ADAM33s with potential metalloprotease activity / Gene 282:227~236
Tsao BP / 2004 / Update on human systemic lupus erythematosus genetics / Curr Opin Rheumatol 16:513~521
Herrmann M / 2000 / Etiopathogenesis of systemic lupus erythematosus / Immunol Today 21:424~426
Gunn TM / 2002 / Identification and preliminary characterization of mouse Adam33 / BMC Genet 3:2
Yoshinaka T / 2002 / Identification and characterization of novel mouse and human ADAM33s with potential metalloprotease activity / Gene 282:227~236
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