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Associations Between Circulating Interleukin-17 Levels and Systemic Lupus Erythematosus and Between Interleukin-17 Gene Polymorphisms and Disease Susceptibility: A Meta-analysis
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논문 기본 정보

Type
Academic journal
Author
Young Ho Lee (Department of Rheumatology Korea University College of Medicine Seoul Korea) Gwan Gyu Song (고려대학교)
Journal
Elementary Education Research Center 대한류마티스학회지 대한류마티스학회지 제27권 제1호 KCI Accredited Journals
Published
2020.1
Pages
37 - 44 (8page)

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Associations Between Circulating Interleukin-17 Levels and Systemic Lupus Erythematosus and Between Interleukin-17 Gene Polymorphisms and Disease Susceptibility: A Meta-analysis
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To systematically investigate the relationship between circulating interleukin-17 (IL-17) levels and systemic lupus erythematosus (SLE) and associations between polymorphisms in IL17 genes and SLE susceptibility. Methods. We performed a meta-analysis of serum/plasma IL-17 levels in patients with SLE and controls and evaluated the associations between the IL17A rs2275913, IL17F rs763780, and IL17F rs2397084 polymorphisms and IL17F copy number variations (CNVs) and risk of SLE. Results. Thirteen studies focusing on 2,096 patients with SLE and 2,587 controls were included. Our meta-analysis revealed that IL-17 levels were significantly higher in the SLE group than the control group (standardized mean difference=1.045, 95% confidence interval [95% CI]=0.521∼1.568, p＜0.001). Subgroup analysis using sample size showed increased IL-17 levels in samples from large (n＞100) but not small (n＜90) SLE groups. We found no evidence of associations between SLE and the IL17A rs2275913, IL17F rs763780, and IL17F rs2397084 polymorphisms. However, a significant association was found between SLE and IL17F CNVs in a pooled cohort of affected individuals compared to that in pooled controls (odd ratio=3.663, 95% CI=2.466∼5.221, p＜0.001). Conclusion. This meta-analysis revealed significantly higher circulating IL-17 levels in patients with SLE and showed evidence of associations between IL17F CNVs and SLE.
#Interleukin-17 #Polymorphism #Systemic lupus erythematosus

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References (29)

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Ruiz-Irastorza G / 2001 / Systemic lupus erythematosus / Lancet 357:1027~1032 google schola Kotzin BL / 1996 / Systemic lupus erythematosus / Cell 85:303~306 google schola Lee YH / 2012 / Genome-wide pathway analysis of genome-wide association studies on systemic lupus erythematosus and rheumatoid arthritis / Mol Biol Rep 39:10627~10635 google schola Kawaguchi M / 2004 / IL-17 cytokine family / J Allergy Clin Immunol 114:1265~1273 google schola Pappu R / 2011 / The interleukin-17 cytokine family : critical players in host defence and inflammatory diseases / Immunology 134:8~16 google schola

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