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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 239 - 247 (9page)
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초록· 키워드
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Objective. To identify the prevalence of antiphospholipid antibodies (aPL) in systemic lupus erythematosus (SLE) patients and determine the relationship between aPL and the clinical outcomes. Methods. SLE patients with aPL test results within 2 years of enrollment were selected from Korean lupus network study. They were classified into two groups: aPL (+) group, patients positive for at least one aPL, and aPL (−) group, patients without an aPL. The clinical characteristics of the two groups were compared and the role of aPL in the risk of chronic kidney disease (CKD) in SLE patients was examined. Results. Among the 469 SLE patients, 69 (14.7%) had at least one aPL. The prevalence of cerebrovascular disease and CKD was higher in the aPL (+) group than in the aPL (−) group (10.1% vs. 1.8% and 13.8% vs. 5.1%, p＜0.05). Multivariable regression analysis showed that the aPL positivity (odds ratio=3.93, 95% confidence interval=1.48∼10.47) was associated with the risk of CKD after adjusting for age, disease duration, and lupus nephritis history. Conclusion. The prevalence of aPL in Korean SLE patients is 14.7%, and it is associated with a higher prevalence of cerebrovascular disease and CKD in SLE patients. The aPL positivity is independently associated with the risk of CKD in SLE patients.
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참고문헌 (38)
참고문헌 신청
George D / 2009 / Antiphospholipid syndrome / Prog Cardiovasc Dis 52:115~125
Petri M / 2000 / Epidemiology of the antiphospholipid antibody syndrome / J Autoimmun 15:145~151
Cervera R / 2015 / Morbidity and mortality in the antiphospholipid syndrome during a 10-year period: a multicentre prospective study of 1000 patients / Ann Rheum Dis 74:1011~1018
Mok CC / 2005 / Incidence and risk factors of thromboembolism in systemic lupus erythematosus: a comparison of three ethnic groups / Arthritis Rheum 52:2774~2782
Pons-Estel GJ / 2017 / The antiphospholipid syndrome in patients with systemic lupus erythematosus / J Autoimmun 76:10~20
Petri M / 2000 / Epidemiology of the antiphospholipid antibody syndrome / J Autoimmun 15:145~151
Cervera R / 2015 / Morbidity and mortality in the antiphospholipid syndrome during a 10-year period: a multicentre prospective study of 1000 patients / Ann Rheum Dis 74:1011~1018
Mok CC / 2005 / Incidence and risk factors of thromboembolism in systemic lupus erythematosus: a comparison of three ethnic groups / Arthritis Rheum 52:2774~2782
Pons-Estel GJ / 2017 / The antiphospholipid syndrome in patients with systemic lupus erythematosus / J Autoimmun 76:10~20
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