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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Objective. To evaluate the association between circulating adiponectin, visfatin, and ghrelin levels and systemic lupus erythematosus (SLE). Methods. We conducted a meta-analysis to compare serum/plasma adiponectin, visfatin, and ghrelin levels in patients with SLE to those of healthy controls. Results. Eleven articles (822 patients with SLE and 676 controls) were included in the meta-analysis. The meta-analysis showed that the adiponectin level was significantly higher in the SLE group than in the control group (standardized mean difference [SMD]=0.360, 95% confidence interval [CI]=0.025∼0.695, p=0.035). Stratification according to region showed that high adiponectin levels were associated with SLE in the Western population (SMD=0.225, 95% CI=0.024∼0.426, p=0.028), but not in the South American population. A subgroup analysis that adiponectin level is significantly higher in the SLE group than in the control after adjustment for age, sex, body mass index, large sample size (n＞100); and mean age＞40 years (SMD=0.492, 95% CI=0.065∼0.920, p=0.024; SMD=0.492, 95% CI=0.065∼ 0.920, p=0.024; SMD=0.429, 95% CI=0.124∼0.733, p=0.006, respectively). Stratification by region showed significantly increased visfatin and ghrelin levels in the SLE group in Western and South American populations. Conclusion. Our meta-analysis demonstrated that circulating adiponectin, visfatin, and ghrelin levels are significantly higher in SLE. (J Rheum Dis 2017;24: 99-107)
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참고문헌 (40)
참고문헌 신청
Ruiz-Irastorza G / 2001 / Systemic lupus erythematosus / Lancet 357:1027~1032
Shao WH / 2011 / Disturbances of apoptotic cell clearance in systemic lupus erythematosus / Arthritis Res Ther 13:202
Coelho M / 2013 / Biochemistry of adipose tissue : an endocrine organ / Arch Med Sci 9:191~200
Shehzad A / 2012 / Adiponectin : regulation of its production and its role in human diseases / Hormones(Athens) 11:8~20
Cheng X / 2012 / Adiponectin induces pro-inflammatory programs in human macrophages and CD4+ T cells / J Biol Chem 287:36896~36904
Shao WH / 2011 / Disturbances of apoptotic cell clearance in systemic lupus erythematosus / Arthritis Res Ther 13:202
Coelho M / 2013 / Biochemistry of adipose tissue : an endocrine organ / Arch Med Sci 9:191~200
Shehzad A / 2012 / Adiponectin : regulation of its production and its role in human diseases / Hormones(Athens) 11:8~20
Cheng X / 2012 / Adiponectin induces pro-inflammatory programs in human macrophages and CD4+ T cells / J Biol Chem 287:36896~36904
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