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논문 기본 정보

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학술저널
저자정보
Sudhakar Pushpa Chaithra (National Institute of Mental Health and Neurosciences) Shweta Prasad (National Institute of Mental Health & Neurosciences) Vikram Venkappayya Holla (National Institute of Mental Health and Neurosciences) Albert Stezin (National Institute of Mental Health and Neurosciences) Nitish Kamble (National Institute of Mental Health and Neurosciences) Ravi Yadav (National Institute of Mental Health and Neurosciences) Pramod Kumar Pal (National Institute of Mental Health & Neurosciences)
저널정보
대한파킨슨병및이상운동질환학회 Journal Of Movement Disorders Journal Of Movement Disorders Vol.13 No.2
발행연도
2020.1
수록면
118 - 126 (9page)

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ObjectiveaaNon-motor symptoms (NMSs) significantly contribute to increased morbidity and poor quality of life in patients withparkinsonian disorders. This study aims to explore the profile of NMSs in patients with progressive supranuclear palsy (PSP) usingthe validated Non-Motor Symptom Scale (NMSS). MethodsaaSeventy-six patients with PSP were evaluated in this study. Motor symptoms and NMSs were evaluated using the PSPRating Scale (PSPRS), Unified Parkinson’s Disease Rating Scale-III, Montreal Cognitive Assessment, Hamilton Depression (HAMD)and Anxiety Rating Scales, Parkinson’s Disease Sleep Scale (PDSS) and NMSS. NMS severity and prevalence were also comparedbetween patients with PSP-Richardson syndrome (PSP-RS) and those with PSP-parkinsonism. ResultsaaAll subjects in this cohort reported at least 2 NMSs. The most prevalent NMSs in patients with PSP were in the domainsof sleep/fatigue, mood/cognition, and sexual function. The least prevalent NMSs were in the domains of cardiovascular includingfalls, and perceptual problems/hallucinations. Significant correlations were observed between the NMSS scores and HAM-D,PDSS, PSPRS scores and PSPRS sub-scores. The severity of NMSs was unrelated to the duration of illness. Patients with PSP-RSreported a higher severity of drooling, altered smell/taste, depression and altered interest in sex and a higher prevalence of sexualdysfunction. ConclusionaaNMSs are commonly observed in patients with PSP, and the domains of sleep, mood and sexual function aremost commonly affected. These symptoms contribute significantly to disease morbidity, and clinicians should pay adequate attentionto identifying and addressing these symptoms.
#Cognitive dysfunction #Depression #Mood #Progressive supranuclear palsy #Sleep.

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참고문헌 (29)

참고문헌 신청
Chaudhuri KR / 2006 / Non-motor symptoms of Parkinson’s disease: diagnosis and management / Lancet Neurol 5:235~245 google schola Martinez-Martin P / 2011 / The impact of non-motor symptoms on health-related quality of life of patients with Parkinson’s disease / Mov Disord 26:399~406 google schola Chaudhuri KR / 2013 / A proposal for a comprehensive grading of Parkinson’s disease severity combining motor and non-motor assessments: meeting an unmet need / PLoS One 8:e57221 google schola Muzerengi S / 2007 / Non-motor symptoms: identification and management / Parkinsonism Relat Disord 13(Suppl 3):S450~S456 google schola Zis P / 2015 / Non-motor symptoms burden in treated and untreated early Parkinson’s disease patients: argument for non-motor subtypes / Eur J Neurol 22:1145~1150 google schola

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