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자료유형
학술저널
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대한신경과학회 Journal of Clinical Neurology Journal of Clinical Neurology 제11권 제3호
발행연도
2015.1
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268 - 274 (7page)

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Background and Purpose Various magnetic resonance (MR) measurements have been proposed to aid in diferentiating between progressive supranuclear palsy (PSP) and idiopathic Parkinson’s disease (IPD); however, these methods have not been compared directly. Te aim of this study was to determine which measurement method exhibits the highest power to diferentiate between PSP and IPD. Methods Brain MR images from 82 IPD and 29 PSP patients were analyzed retrospectively. T1-weighted 3D volumetric axial images, or sagittal images reconstructed from those axial images were examined. MR measurements included the length from the interpeduncular fossa to the center of the cerebral aqueduct at the mid-mammillary-body level, adjusted according to the anterior commissure–posterior commissure length (MBTegm), the ratio of the midbrain area to the pons area (M/P ratio) as measured by both Oba’s method (Oba M/P) and Cosottini’s method (Cosottini M/P), and a modifed MR parkinsonism index (mMRPI). Results Receiver operating characteristic (ROC) analysis indicated that the areas under the ROC curves (AUCs) exceeded 0.70, with a high intrarater reliability for all MR measurement methods. ROC analyses of four MR measurements yielded AUCs of 0.69–0.76. At the cutof value with the highest Youden index, mMRPI had the highest sensitivity, while Oba M/P offered the highest specifcity. A comparison of the ROC analyses revealed that MB Tegm was superior to mMRPI in diferentiating PSP from IPD (p=0.049). Tere was no diference in discriminating power among Oba M/P, Cosottini M/P, and MB Tegm. Conclusions Simple measurements of MB Tegm on axial MR images at the mid-mammillarybody level are comparable to measurements of the M/P ratio with regard to their ability to discriminate PSP from IPD.

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