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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 169 - 172 (4page)
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Present study investigated the morphologic changes of autonomic nerves in the adipose tissue in diabetic animal model. Male obese type 2 diabetic db/db mice and age matched non-diabetic db/m control mice were used. Epididymal adipose tissue from diabetic db/db mice with that from control heterozygous db/m mice was compared using confocal microscopy-based method to visualize intact whole adipose tissue. Immunohistochemistry with tyrosine hydroxylase for sympathetic (SP), choline acetyltransferase for parasympathetic (PSP), and protein gene product 9.5 (PGP 9.5) for whole autonomic nerves was performed. The quantity of immunostained portion of SP, PSP, and PGP 9.5 stained nerve fibers showed decreased trend in diabetic group; however, the ratio of SP/PSP of adipose tissue was higher in diabetic group compared with control group as follows (0.70±0.30 vs. 0.95±0.25, P<0.05; normal vs. diabetic, respectively). Both SP and PSP nerve fibers were observed in white adipose tissue and PSP nerve fibers were suggested as more decreased in diabetes based on our observation.
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등록된 정보가 없습니다.
참고문헌 (14)
참고문헌 신청
Kershaw EE / 2004 / Adipose tissue as an endocrine organ / J Clin Endocrinol Metab 89:2548~2556
장은희 / 2012 / Influence of Visceral Adiposity on Cardiovascular Autonomic Neuropathy in Patients with Type 2 Diabetes Mellitus / Diabetes and Metabolism Journal 36(4):285~292
Bittel DC / 2015 / Adipose tissue content, muscle performance and physical function in obese adults with type 2 diabetes mellitus and peripheral neuropathy / J Diabetes Complications 29:250~257
Voulgari C / 2011 / The association between cardiac autonomic neuropathy with metabolic and other factors in subjects with type 1 and type 2 diabetes / J Diabetes Complications 25:159~167
Fliers E / 2002 / Adipose tissue: an innervated endocrine gland / Ned Tijdschr Geneeskd 146:1976~1979
장은희 / 2012 / Influence of Visceral Adiposity on Cardiovascular Autonomic Neuropathy in Patients with Type 2 Diabetes Mellitus / Diabetes and Metabolism Journal 36(4):285~292
Bittel DC / 2015 / Adipose tissue content, muscle performance and physical function in obese adults with type 2 diabetes mellitus and peripheral neuropathy / J Diabetes Complications 29:250~257
Voulgari C / 2011 / The association between cardiac autonomic neuropathy with metabolic and other factors in subjects with type 1 and type 2 diabetes / J Diabetes Complications 25:159~167
Fliers E / 2002 / Adipose tissue: an innervated endocrine gland / Ned Tijdschr Geneeskd 146:1976~1979
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