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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.12
- 수록면
- 1,045 - 1,055 (11page)
- DOI
- 10.1007/s13770-021-00384-7
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초록· 키워드
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Background: Stem cells intra-articular injection stagey indicated a potential therapeutic effect on improving the pathological progress of osteoarthritis (OA). However, the long-term effect of stem cells intra-articular injection on the cartilage regeneration remains unclear. miR-29a-3p is predicted to be a critical target for inhibiting insulin-like growth factor-1 expression and may aggravate the progression of OA.
Methods: In this study, we investigated the therapeutic efficacy of intra-articular injection of bone marrow mesenchymal stem cells (BMSCs) transfected with miR-29a-3p inhibitor in OA.
Results: miR-29a-3p inhibitor transfection did not influence cell viability of BMSCs, while the chondrogenic differentiation potential of BMSCs was significantly improved. Interestingly, intra-articular injection of BMSCs with miR-29a-3p inhibition significantly prevented articular cartilage degeneration by up-regulating the expression of Sox 9, Col-2a1, aggrecan and down-regulating the expression of matrix metalloproteinase, as well as relieved pain in OA.
Conclusion: The double effects on cartilage protection and pain relief indicated a great potential of intra-articular injection of miR-29a-3p inhibitor-transfected BMSCs for the treatment of OA.
목차
등록된 정보가 없습니다.
참고문헌 (34)
참고문헌 신청
Murphy JM / 2003 / Stem cell therapy in a caprine model of osteoarthritis / Arthritis Rheum 48:3464~3474
Centeno CJ / 2008 / Increased knee cartilage volume in degenerative joint disease using percutaneously implanted / Pain Physician 11:343~353
Csaki C / 2008 / Mesenchymal stem cells as a potential pool for cartilage tissue engineering / Ann Anat 190:395~412
Maumus M / 2011 / Mesenchymal stem cell-based therapies in regenerative medicine : applications in rheumatology / Stem Cell Res Ther 2:14
Barry F / 2013 / Mesenchymal stem cells in joint disease and repair / Nat Rev Rheumatol 9:584~594
Centeno CJ / 2008 / Increased knee cartilage volume in degenerative joint disease using percutaneously implanted / Pain Physician 11:343~353
Csaki C / 2008 / Mesenchymal stem cells as a potential pool for cartilage tissue engineering / Ann Anat 190:395~412
Maumus M / 2011 / Mesenchymal stem cell-based therapies in regenerative medicine : applications in rheumatology / Stem Cell Res Ther 2:14
Barry F / 2013 / Mesenchymal stem cells in joint disease and repair / Nat Rev Rheumatol 9:584~594
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