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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 105 - 119 (15page)
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BACKGROUND: We first determined the efficacy of lesional injection of tonsil-derived MSCs (mesenchymal stem cells) for the treatment of 5-fluorouracil induced oral mucositis. METHODS: Oral mucositis was induced in hamsters by administration of 5-fluorouracil (day 0, 2, 4) followed by mechanical trauma (day 1, 2, 4). The experimental groups included MT (mechanical trauma only), 5-FU ? MT (mechanical trauma with 5-fluorouracil administration), TMSC (mechanical trauma with 5-fluorouracil administration, tonsilderived mesenchymal stem cells injection), DEXA (mechanical trauma with 5-fluorouracil administration, dexamethasone injection), and saline (mechanical trauma with 5-fluorouracil administration, saline injection). RESULTS: On day 10, gross and histologic analyses showed that nearly complete healing and epithelialization of the cheek mucosa of the TMSC group, whereas the other groups showed definite ulcerative lesions. Compared with the MT and DEXA groups, CD31 expression was greater in the TMSC group on days 10 and 14. Tendency towards a decrease in MMP2 expression with the time in the TMSC group was observed. In addition, the TMSC group showed higher expression of TGF-b, and NOX4 on day 10 compared with the other groups. Scratch assay demonstrated that the conditioned media harvested from tonsil-derived MSCs significantly increased migratory efficacy of NIH3T3 cells. Transwell assay showed that the preferential migration of tonsil-derived MSCs to the wound area. CONCLUSION: Intralesional administration of tonsil-derived MSCs may accelerate wound healing of 5-fluorouracil induced oral mucositis by upregulating neovascularization and effective wound contraction. In addition, tonsil-derived MSCs might contribute to oral ulcer regeneration via the stimulation of fibroblast proliferation and migration.
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참고문헌 (37)
참고문헌 신청
Elting LS / 2003 / The burdens of cancer therapy : clinical and economic outcomes of chemotherapy-induced mucositis / Cancer 98:1531~1539
Horii K / 2014 / Platelet-rich fibrin has a healing effect on chemotherapy-induced mucositis in hamsters / Oral Surg Oral Med Oral Pathol Oral Radiol 117:445~453
Tanideh N / 2013 / Healing acceleration in hamsters of oral mucositis induced by 5-fluorouracil with topical Calendula officinalis / Oral Surg Oral Med Oral Pathol Oral Radiol 115:332~338
Biswal BM / 2008 / Current trends in the management of oral mucositis related to cancer treatment / Malays J Med Sci 15:4~13
Lalla RV / 2008 / Management of oral mucositis in patients who have cancer / Dent Clin North Am 52:61~77
Horii K / 2014 / Platelet-rich fibrin has a healing effect on chemotherapy-induced mucositis in hamsters / Oral Surg Oral Med Oral Pathol Oral Radiol 117:445~453
Tanideh N / 2013 / Healing acceleration in hamsters of oral mucositis induced by 5-fluorouracil with topical Calendula officinalis / Oral Surg Oral Med Oral Pathol Oral Radiol 115:332~338
Biswal BM / 2008 / Current trends in the management of oral mucositis related to cancer treatment / Malays J Med Sci 15:4~13
Lalla RV / 2008 / Management of oral mucositis in patients who have cancer / Dent Clin North Am 52:61~77
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