The Therapeutic Potential of Extracellular Vesicles Versus Mesenchymal Stem Cells in Liver Damage

Rostom Dina M.; Attia Noha; Khalifa Hoda M.; Abou Nazel Maha W.; El Sabaawy Eshrak A.

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자료유형: 학술저널

저자정보: Rostom Dina M. (University of Alexandria) Attia Noha (University of Alexandria) Khalifa Hoda M. (University of Alexandria) Abou Nazel Maha W. (University of Alexandria) El Sabaawy Eshrak A. (University of Alexandria)

저널정보: 한국조직공학과 재생의학회 조직공학과 재생의학 조직공학과 재생의학 제17권 제4호

발행연도: 2020.1

수록면: 537 - 552 (16page)

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Background: The extracellular vesicles (EVs) secreted by bone marrow-derived mesenchymal stem cells (MSCs) hold significant potential as a novel alternative to whole-cell therapy. We herein compare the therapeutic potential of BM-MSCs versus their EVs (MSC-EVs) in an experimental Carbon tetrachloride (CCl4)-induced liver damage rat model. Methods: Rats with liver damage received a single IV injection of MSC-EVs, 1 million MSCs, or 3 million MSCs. The therapeutic efficacy of each treatment was assessed using liver histopathology, liver function tests and immunohistochemistry for liver fibrosis and hepatocellular injury. Results: Animals that received an injection of either MSCs-EVs or 3 million MSCs depicted significant regression of collagen deposition in the liver tissue and marked attenuation of hepatocellular damage, both structurally and functionally. Conclusion: Similar to high doses of MSC-based therapy (3 million MSCs), MSC-EVs mitigated the fibrogenesis and hepatocellular injury in a rat model of CCl4-induced liver fibrosis. The anti-fibrinogenic effect was induced by attenuating hepatic stellate cell activation. Therefore, the administration of MSC-EVs could be considered as a candidate cell-free therapeutic strategy for liver fibrosis and hepatocellular damage.

#Extracellular vesicles Exosomes Bone marrow-derived stem cells Liver fibrosis Conditioned media

참고문헌 (56)

참고문헌 신청

Asrani SK / 2019 / Burden of liver diseases in the world / J Hepatol 70:151~171

Hernandez-Gea V / 2011 / Pathogenesis of liver fibrosis / Annu Rev Pathol 6:425~456

Tsolaki E / 2015 / Stem cell-based regenerative opportunities for the liver : state of the art and beyond / World J Gastroenterol 21:12334~12350

Mahla RS / 2016 / Stem cells applications in regenerative medicine and disease therapeutics / Int J Cell Biol 2016:6940283

Wei X / 2013 / Mesenchymal stem cells : a new trend for cell therapy / Acta Pharmacol Sin 34:747~754

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