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논문 기본 정보

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학술저널
저자정보
최다현 (충북대학교) Park Jiwon (Chungbuk National University) 최주광 (충북대학교) 이경은 (충북대학교) 이원희 (주식회사 엠디헬스케어) Jinho Yang (주식회사 엠디헬스케어) Ju Yeon Lee (Seoul National University) Yoon Jeong Park (Seoul National University) 오찬 (충남대학교) 원호륜 (충남대학교) 구본석 (충남대학교) 장재원 (충남대학교) 박윤신 (충북대학교)
저널정보
대한생화학·분자생물학회 Experimental and Molecular Medicine Experimental and Molecular Medicine 제52권
발행연도
2020.9
수록면
12 - 21 (10page)
DOI
10.1038/s12276-020-00487-6

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Oral microbes have the capacity to spread throughout the gastrointestinal system and are strongly associated with multiple diseases. Given that tonsils are located between the oral cavity and the laryngopharynx at the gateway of the alimentary and respiratory tracts, tonsillar tissue may also be affected by microbiota from both the oral cavity (saliva) and the alimentary tract. Here, we analyzed the distribution and association of the microbial communities in the saliva and tonsils of Korean children subjected to tonsillectomy because of tonsil hyperplasia (n = 29). The microbiome profiles of saliva and tonsils were established via 16S rRNA gene sequencing. Based on the alpha diversity indices, the microbial communities of the two groups showed high similarities. According to Spearman’s ranking correlation analysis, the distribution of Treponema, the causative bacterium of periodontitis, in saliva and tonsils was found to have a significant positive correlation. Two representative microbes, Prevotella in saliva and Alloprevotella in tonsils, were negatively correlated, while Treponema 2 showed a strong positive correlation between saliva and tonsils. Taken together, strong similarities in the microbial communities of the tonsils and saliva are evident in terms of diversity and composition. The saliva microbiome is expected to significantly affect the tonsil microbiome. Furthermore, we suggest that our study creates an opportunity for tonsillar microbiome research to facilitate the development of novel microbiome-based therapeutic strategies.

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