Liver Infarction and Venous Thromboembolism after Tamoxifen Use in an ADPKD Patient with Encapsulating Peritoneal Sclerosis: A Case Report

Kyoung Min Kwak; Gwang Ho Choi; Kwang Eon Shim; Ho Yong Jin; Seok Hyung Kim; Jong Woo Yoon; Hyunsuk Kim

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저자정보: Kyoung Min Kwak (Department of Internal Medicine Hallym University Chuncheon Sacred Heart Hospital Chuncheon Korea) Gwang Ho Choi (Department of Internal Medicine Hallym University Chuncheon Sacred Heart Hospital Chuncheon Korea) Kwang Eon Shim (Department of Internal Medicine Hallym University Chuncheon Sacred Heart Hospital Chuncheon Korea) Ho Yong Jin (Department of Internal Medicine Hallym University Chuncheon Sacred Heart Hospital Chuncheon Korea) Seok Hyung Kim (Department of Internal Medicine Hallym University Chuncheon Sacred Heart Hospital Chuncheon Korea) Jong Woo Yoon (Department of Internal Medicine Hallym University Chuncheon Sacred Heart Hospital Chuncheon Korea) Hyunsuk Kim (Department of Internal Medicine Hallym University Chuncheon Sacred Heart Hospital Chuncheon Korea)

저널정보: 전해질고혈압연구회 Electrolytes & Blood Pressure Electrolytes & Blood Pressure Vol.18 No.2

발행연도: 2020.1

수록면: 44 - 48 (5page)

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Encapsulating peritoneal sclerosis(EPS) is a potentially fatal complication after long-term peritoneal dialysis, and tamoxifen can be used for its prevention and treatment. However, tamoxifen is known to increase the risk of venous thromboembolism. A 49-year-old woman was admitted with sudden abdominal pain. The patient had received peritoneal dialysis for 20 years and switched to hemodialysis after the diagnosis of EPS. Tamoxifen (10 mg) and prednisolone (20 mg) had been administered for 8 months. On computed tomography, the left hepatic lobe was hardly illuminated, leading to a diagnosis of liver infarction. A month later, she was re-admitted due to abdominal pain and extensive deep vein thrombosis of the leg. The administration of tamoxifen was stopped and prednisolone was reduced to 10 mg. As her malnutrition progressed, she succumbed to death of gram negative sepsis. The patient was concluded to have liver infarction and extensive venous thrombosis as a side effect of tamoxifen.

#Encapsulating peritoneal sclerosis #Liver infarction #Tamoxifen #Venous thromboembolism

참고문헌 (25)

참고문헌 신청

Mihalache O / 2014 / Encapsulating peritoneal sclerosis: A rare and serious complication of peritoneal dialysis: case series / J Med Life 7(3):8~12

Kawanishi H / 2005 / Successful surgical management of encapsulating peritoneal sclerosis / Perit Dial Int 25(Suppl 4):S39~S47

Hendrick A / 1980 / Tamoxifen and thromboembolism / JAMA 243(6):514~515

Kovac M / 2015 / Factor V leiden mutation and high FVIII are associated with an increased risk of VTE in women with breast cancer during adjuvant tamoxifen : results from a prospective, single center, case control study / Eur J Intern Med 26(1):63~67

Eroglu A / 2013 / Tamoxifen-associated thromboembolism in breast cancer / Thromb Res 131(6):566

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