지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.7
- 수록면
- 491 - 498 (8page)
- DOI
- https://doi.org/10.4306/pi.2017.14.4.491
이용수
초록· 키워드
오류제보하기
Objective: Tamoxifen is an estrogen receptor antagonist used to prevent recurrence of breast cancer, which may provoke depression and anxiety and increase follicle-stimulating hormone (FSH) to patients. We compared anxiety and depression symptoms and FSH levels who received conventional tamoxifen alone and combination treatment of goserelin, a gonadotropin-releasing hormone (GnRH) analogue, with tamoxifen.
Methods: Sixty-four premenopausal women with hormone receptor-positive early-stage breast cancer were included and were assigned randomly to receive either tamoxifen and goserelin combination or tamoxifen alone for 12 months. The participants were evaluated blindly using the Hamilton Depression and Anxiety Rating Scale, the Beck Depression Rating Scale, and the Albany Panic and Phobia Questionnaire (APPQ). Blood FSH levels were assessed at baseline, 6 and 12 months.
Results: A significant time×group difference was detected in the agoraphobia trends subscale of the APPQ and in FSH levels. The combination group showed significantly less increases in agoraphobia subscale of APPQ and greater decreases in FSH level than those in the tamoxifen-alone group from baseline to 12 months of treatment. No significant differences for age, tumor grade, body mass index, or family history were found at baseline between the two groups.
Conclusion: Our results suggest that the combination treatment of tamoxifen and goserelin resulted in less agoraphobia than tamoxifen alone in premenopausal women with breast cancer, which may associated with FSH suppression of goserelin.
목차
등록된 정보가 없습니다.
참고문헌 (47)
참고문헌 신청
Dellapasqua S / 2005 / Adjuvant endocrine therapy for premenopausal women with early breast cancer / J Clin Oncol 23:1736~1750
Carlson RW / 2009 / Breast cancer / J Nat Compr Cancer Network 7:122~192
Burstein HJ / 2010 / American Society of Clinical Oncology clinical practice guideline : update on adjuvant endocrine therapy for women with hormone receptor-positive breast cancer / J Clin Oncol 28:3784~3796
Goldhirsch A / 2013 / Personalizing the treatment of women with early breast cancer : highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2013 / Ann Oncol 24:2206~2223
Gjerde J / 2010 / Associations between tamoxifen, estrogens, and FSH serum levels during steady state tamoxifen treatment of postmenopausal women with breast cancer / BMC Cancer 10:313
Carlson RW / 2009 / Breast cancer / J Nat Compr Cancer Network 7:122~192
Burstein HJ / 2010 / American Society of Clinical Oncology clinical practice guideline : update on adjuvant endocrine therapy for women with hormone receptor-positive breast cancer / J Clin Oncol 28:3784~3796
Goldhirsch A / 2013 / Personalizing the treatment of women with early breast cancer : highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2013 / Ann Oncol 24:2206~2223
Gjerde J / 2010 / Associations between tamoxifen, estrogens, and FSH serum levels during steady state tamoxifen treatment of postmenopausal women with breast cancer / BMC Cancer 10:313
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