지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.8
- 수록면
- 201 - 208 (8page)
- DOI
- 10.15188/kjopp.2020.08.34.4.201
이용수
초록· 키워드
오류제보하기
The effects of Gamisoyo-san (GMSYS) co-administration within 5 min on the pharmacokinetics (PK) of tamoxifen were observed. After 50 mg/kg of tamoxifen oral treatment, GMSYS 100 mg/kg was orally administered within 5 min to 7-wk old male SPF.VAF Outbred Crl:CD [Sprague-Dawley (SD)] rats. The plasma were collected at 30 min before administration, 30 min, 1, 2, 3, 4, 6, 8 and 24 hrs after end of GMSYS treatment, and plasma concentrations of tamoxifen were analyzed using LC-MS/MS methods. Tmax, Cmax, AUC, t1/2 and MRTinf of tamoxifen were analysis as compared with tamoxifen single administered rats. Although co-administration with GMSYS did not critically influenced on the pharmacokinetic parameters of oral tamoxifen, they induced increased trends of plasma tamoxifen concentrations, especially significant (p<0.05) increases of plasma tamoxifen concentrations were demonstrated at 0.5 hr after end of co-administration with GMSYS as compared with tamoxifen single formula treated rats, at dosage levels of tamoxifen 10 mg/kg and GMSYS 100 mg/kg within 5 min. It is considered that pharmacokinetic studies should be tested like the effects of GMSYS on the pharmacokinetics of tamoxifen, when they were co-administered with prolonger intervals than Tmax of tamoxifen oral administration (about 2.5 hr-intervals), to achieve the optimal dosing regimen of GMSYS and tamoxifen co-administration.
목차
Introduction
Materials and Methods
Results
Discussion
Conclusion
References
참고문헌 (42)
참고문헌 신청
The BIG 1-98 Collaborative Group / 2009 / Letrozole therapy alone or in sequence with tamoxifen in women with breast cancer / N Engl J Med 361(8):766~776
Jordan VC / 2006 / Tamoxifen (ICI46,474) as a targeted therapy to treat and prevent breast cancer / Br J Pharmacol 147(Suppl 1):S269~S276
van Bommel EF / 2006 / Brief communication: tamoxifen therapy for nonmalignant retroperitoneal fibrosis / Ann Intern Med 144(2):101~106
Fradet Y / 2007 / Tamoxifen as prophylaxis for prevention of gynaecomastia and breast pain associated with bicalutamide 150 mg monotherapy in patients with prostate cancer: a randomised, placebo-controlled, dose-response study / Eur Urol 52(1):106~114
Hurtado A / 2008 / Regulation of ERBB2 by oestrogen receptor-PAX2 determines response to tamoxifen / Nature 456(7222):663~666
Jordan VC / 2006 / Tamoxifen (ICI46,474) as a targeted therapy to treat and prevent breast cancer / Br J Pharmacol 147(Suppl 1):S269~S276
van Bommel EF / 2006 / Brief communication: tamoxifen therapy for nonmalignant retroperitoneal fibrosis / Ann Intern Med 144(2):101~106
Fradet Y / 2007 / Tamoxifen as prophylaxis for prevention of gynaecomastia and breast pain associated with bicalutamide 150 mg monotherapy in patients with prostate cancer: a randomised, placebo-controlled, dose-response study / Eur Urol 52(1):106~114
Hurtado A / 2008 / Regulation of ERBB2 by oestrogen receptor-PAX2 determines response to tamoxifen / Nature 456(7222):663~666
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UCI(KEPA) : I410-ECN-0101-2020-519-001172596