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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 320 - 328 (9page)
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The basolateral amygdala (BLA) receives dense projections from cholinergic neurons of the basal forebrain. Acetylcholine can contributes to amygdala-dependent behaviors: formation and extinction of fear memory and appetitive instrumental learning. However, the cholinergic mechanism at the circuit level has not been defined yet. We demonstrated that cholinergic-induced di-synaptic inhibition of BLA pyramidal neurons exhibits a retrograde form of short-term synaptic inhibition, depolarization-induced suppression of inhibition (DSI). Activation of nicotinic receptors was sufficient to evoke action potentials in cholecystokinin (CCK)-positive inhibitory neurons, which strongly inhibit pyramidal neurons through their perisomatic synapses. Our cell type-specific monosynaptic retrograde tracing also revealed that CCK neurons are innervated by basal forebrain cholinergic neurons. Therefore, our data indicated that CCK inhibitory neurons mediate the cholinergic-induced di-synaptic inhibition of BLA pyramidal neurons.
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참고문헌 (30)
참고문헌 신청
Thiele A / 2013 / Muscarinic signaling in the brain / Annu Rev Neurosci 36:271~294
Albuquerque EX / 2009 / Mammalian nicotinic acetylcholine receptors : from structure to function / Physiol Rev 89:73~120
Arroyo S / 2014 / Nicotinic modulation of cortical circuits / Front Neural Circuits 8:30
Dannenberg H / 2017 / Modulation of hippocampal circuits by muscarinic and nicotinic receptors / Front Neural Circuits 11:102
Unal CT / 2015 / Impact of basal forebrain cholinergic inputs on basolateral amygdala neurons / J Neurosci 35:853~863
Albuquerque EX / 2009 / Mammalian nicotinic acetylcholine receptors : from structure to function / Physiol Rev 89:73~120
Arroyo S / 2014 / Nicotinic modulation of cortical circuits / Front Neural Circuits 8:30
Dannenberg H / 2017 / Modulation of hippocampal circuits by muscarinic and nicotinic receptors / Front Neural Circuits 11:102
Unal CT / 2015 / Impact of basal forebrain cholinergic inputs on basolateral amygdala neurons / J Neurosci 35:853~863
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