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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 179 - 185 (7page)
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Neuronal firing patterns and frequencies determine the nature of encoded information of the neurons. Here we discuss the molecular identity and cellular mechanisms of spike-frequency adaptation in central nervous system (CNS) neurons. Calcium-activated potassium (KCa) channels such as BKCa and SKCa channels have long been known to be important mediators of spike adaptation via generation of a large afterhyperpolarization when neurons are hyper-activated. However, it has been shown that a strong hyperpolarization via these KCa channels would cease action potential generation rather than reducing the frequency of spike generation. In some types of neurons, the strong hyperpolarization is followed by oscillatory activity in these neurons. Recently, spike-frequency adaptation in thalamocortical (TC) and CA1 hippocampal neurons is shown to be mediated by the Ca2+-activated Cl- channel (CACC), anoctamin-2 (ANO2). Knockdown of ANO2 in these neurons results in significantly reduced spike-frequency adaptation accompanied by increased number of spikes without shifting the firing mode, which suggests that ANO2 mediates a genuine form of spike adaptation, finely tuning the frequency of spikes in these neurons. Based on the finding of a broad expression of this new class of CACC in the brain, it can be proposed that the ANO2-mediated spike-frequency adaptation may be a general mechanism to control information transmission in the CNS neurons.
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참고문헌 (40)
참고문헌 신청
Partridge LD / 1976 / A mechanism for spike frequency adaptation / J Physiol 256:315~332
Baldissera F / 1978 / Saturating summation of the afterhyperpolarization conductance in spinal motoneurones: a mechanism for ‘secondary range’ repetitive firing / Brain Res 146:69~82
Wilson CJ / 2004 / A model of reverse spike frequency adaptation and repetitive firing of subthalamic nucleus neurons / J Neurophysiol 91:1963~1980
Shinomoto S / 2003 / Differences in spiking patterns among cortical neurons / Neural Comput 15:2823~2842
Velumian AA / 1999 / Differential control of three after-hyperpolarizations in rat hippocampal neurones by intracellular calcium buffering / J Physiol 517:201~216
Baldissera F / 1978 / Saturating summation of the afterhyperpolarization conductance in spinal motoneurones: a mechanism for ‘secondary range’ repetitive firing / Brain Res 146:69~82
Wilson CJ / 2004 / A model of reverse spike frequency adaptation and repetitive firing of subthalamic nucleus neurons / J Neurophysiol 91:1963~1980
Shinomoto S / 2003 / Differences in spiking patterns among cortical neurons / Neural Comput 15:2823~2842
Velumian AA / 1999 / Differential control of three after-hyperpolarizations in rat hippocampal neurones by intracellular calcium buffering / J Physiol 517:201~216
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