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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 246 - 251 (6page)
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Phosphodiesterases (PDEs) play a key role in the regulation of cyclic adenosine monophosphate (cAMP), which in turn mediates various cellular functions including learning and memory. We previously cloned and characterized three PDE4 isoforms (ApPDE4) from Aplysia kurodai. Using reverse transcription polymerase chain reaction (RT-PCR), we found that ApPDE4 isoforms are primarily expressed in the central nervous system. However, the detailed distribution of ApPDE4 mRNA in Aplysia individual ganglions was not evident. In this study, to determine the distribution of ApPDE4 mRNAs in Aplysia ganglions, we performed in situ hybridization (ISH) using a probe targeting ApPDE4, including the PDE catalytic domain. Interestingly, we found the strongest ISH-positive signals in the symmetrical bag cell clusters of the abdominal ganglion. The R2, R14, L7, L2 and L11 neurons in the abdominal ganglion, LP1 neuron in pleural ganglion, and metacerebral (MCC) neurons were ISH-positive. Mechanosensory neurons of the sensory cluster were also stained on the ventral aspect of the right and left pleural ganglia. Taken together, we found the detailed distribution of ApPDE4 mRNA in Aplysia ganglion and support their roles in serotonin (5-HT)-induced synaptic facilitation of Aplysia mechanosensory neurons.
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참고문헌 (14)
참고문헌 신청
Kandel ER / 2012 / The molecular biology of memory: cAMP, PKA, CRE, CREB-1, CREB-2, and CPEB / Mol Brain 5:14
Lee J / 2014 / Specific targeting of proteins to outer envelope membranes of endosymbiotic organelles, chloroplasts, and mitochondria / Front Plant Sci 5:173
Mu Y / 2014 / Inhibition of phosphodiesterase10A attenuates morphine-induced conditioned place preference / Mol Brain 7:70
Jang DJ / 2010 / N termini of apPDE4 isoforms are responsible for targeting the isoforms to different cellular membranes / Learn Mem 17:469~479
Park H / 2005 / An Aplysia type 4 phosphodiesterase homolog localizes at the presynaptic terminals of Aplysia neuron and regulates synaptic facilitation / J Neurosci 25:9037~9045
Lee J / 2014 / Specific targeting of proteins to outer envelope membranes of endosymbiotic organelles, chloroplasts, and mitochondria / Front Plant Sci 5:173
Mu Y / 2014 / Inhibition of phosphodiesterase10A attenuates morphine-induced conditioned place preference / Mol Brain 7:70
Jang DJ / 2010 / N termini of apPDE4 isoforms are responsible for targeting the isoforms to different cellular membranes / Learn Mem 17:469~479
Park H / 2005 / An Aplysia type 4 phosphodiesterase homolog localizes at the presynaptic terminals of Aplysia neuron and regulates synaptic facilitation / J Neurosci 25:9037~9045
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