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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 141 - 151 (11page)
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초록· 키워드
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Background: This study aimed to systematically review the literature investigating the effect of intravenous (IV) tranexamic acid (TXA) on the perioperative blood loss and amount of transfused blood in patients who underwent spine surgery under general anesthesia. Methods: MEDLINE, EMBASE, and CENTRAL databases were searched for studies published up to June 2017. Randomized controlled trials comparing the intervention of tranexamic acid use with a placebo in corrective spine fusion surgery were included. Outcome measures included intraoperative and postoperative blood loss and perioperative blood transfusion volume. We also conducted subgroup analyses according to the dose of administration of intervention drug. Results: In total, 12 studies involving 875 patients were included in the final analysis. Blood loss decreased in patients treated with perioperative IV TXA by a mean volume of 189.58 ml intraoperatively (95% confidence interval [CI]: 135.82 to 243.34 ml, P < 0.001; I2 = 74%), 121.04 ml postoperatively (95% CI: 84.92 to 157.17 ml, P < 0.001; I2 = 0%), and 285.97 ml in total (95% CI: 190.70 to 381.23 ml, P < 0.001; I2 = 0%). Perioperative transfusion volume also decreased by 162.10 ml in patients who received IV TXA (95% CI: 31.77 to 292.44 ml, P = 0.010; I2 = 47%). Conclusions: Blood loss was reduced in patients who were administered TXA during spine surgery. Additionally, the perioperative volume of blood transfusion decreased in patients who received TXA. Further research is required to confirm the optimal dosage and timing of TXA usage.
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등록된 정보가 없습니다.
참고문헌 (30)
참고문헌 신청
Neilipovitz DT / 2001 / A randomized trial of tranexamic acid to reduce blood transfusion for scoliosis surgery / Anesth Analg 93:82~87
Sethna NF / 2005 / Tranexamic acid reduces intraoperative blood loss in pediatric patients undergoing scoliosis surgery / Anesthesiology 102:727~732
Wong J / 2008 / Tranexamic Acid reduces perioperative blood loss in adult patients having spinal fusion surgery / Anesth Analg 107:1479~1486
Nuttall GA / 2000 / Predictors of blood transfusions in spinal instrumentation and fusion surgery / Spine (Phila Pa 1976) 25:596~601
Seicean A / 2014 / The effect of blood transfusion on short-term, perioperative outcomes in elective spine surgery / J Clin Neurosci 21:1579~1585
Sethna NF / 2005 / Tranexamic acid reduces intraoperative blood loss in pediatric patients undergoing scoliosis surgery / Anesthesiology 102:727~732
Wong J / 2008 / Tranexamic Acid reduces perioperative blood loss in adult patients having spinal fusion surgery / Anesth Analg 107:1479~1486
Nuttall GA / 2000 / Predictors of blood transfusions in spinal instrumentation and fusion surgery / Spine (Phila Pa 1976) 25:596~601
Seicean A / 2014 / The effect of blood transfusion on short-term, perioperative outcomes in elective spine surgery / J Clin Neurosci 21:1579~1585
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