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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 57 - 62 (6page)
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purpose: Tranexamic acid (TXA) is effective in reducing blood loss in primary total knee replacement. Almost all studies used an intravenous form or a topical form. The aim of this study was to assess the blood sparing efficacy and the safety of oral TXA.Materials and Methods: All patients with primary total knee replacement performed in our institute from January 2015 to October 2015 were eligible. Oral TXA group was given 1 g oral TXA 2 hours before induction of anesthesia and 6 hours and 12 hours postoperatively. The control group was not given TXA.results: There were 94 cases in the oral TXA group and 95 cases in the control group. There was no difference in the baseline characteristics. The oral TXA group had a significantly lower hemoglobin drop (1.7 g/dL vs. 2.5 g/dL), lower drain output (154 mL vs. 203 mL), lower hidden blood loss (244 mL vs. 423 mL) and lower total blood loss (398 mL vs. 626 mL). There was no difference in transfusion rate (1.1% vs. 3.2%) and thromboembolic complication. There was no infection or mortality in both groups.conclusions: Oral TXA is effective in reducing blood loss in primary total knee replacement. It is a safe alternative to the intravenous or topical form.
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참고문헌 (21)
참고문헌 신청
Aguilera X / 2013 / Efficacy and safety of fibrin glue and tranexamic acid to prevent postoperative blood loss in total knee arthroplasty : a randomized controlled clinical t
Aguilera X / 2015 / Topical and intravenous tranexamic acid reduce blood loss compared to routine hemostasis in total knee arthroplasty : a multicenter, randomized, controll
Alshryda S / 2014 / A systematic review and meta-analysis of the topical administration of tranexamic acid in total hip and knee replacement / Bone Joint J 96 : 1005 ~ 1015
Alvarez JC / 2008 / Tranexamic acid reduces blood transfusion in total knee arthroplasty even when a blood conservation program is applied / Transfusion 48 : 519 ~ 525
Bradshaw AR / 2012 / Oral tranexamic acid reduces blood loss in total knee replacement arthroplasty / Curr Orthop Prac 23 : 209 ~ 212
Aguilera X / 2015 / Topical and intravenous tranexamic acid reduce blood loss compared to routine hemostasis in total knee arthroplasty : a multicenter, randomized, controll
Alshryda S / 2014 / A systematic review and meta-analysis of the topical administration of tranexamic acid in total hip and knee replacement / Bone Joint J 96 : 1005 ~ 1015
Alvarez JC / 2008 / Tranexamic acid reduces blood transfusion in total knee arthroplasty even when a blood conservation program is applied / Transfusion 48 : 519 ~ 525
Bradshaw AR / 2012 / Oral tranexamic acid reduces blood loss in total knee replacement arthroplasty / Curr Orthop Prac 23 : 209 ~ 212
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