지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 62 - 62 (1page)
이용수
초록· 키워드
오류제보하기
Total knee arthroplasty (TKA) is associated with significant perioperative blood loss and postoperative allogenic blood transfusion. Tranexamic acid (TXA) reversibly blocks lysine binding sites on plasminogen molecules and inhibits plasmin formation. Comparisons of the efficacy and safety of intra-articular and intravenous TXA in primary TKA have not previously been reported.A prospective randomized trial was conducted in 150 patients who underwent TKA, and these patients were randomized into three groups. Patients in Group A were injected by intra-articular TXA according to body weight (20?mg/kg). Patients in Group B received a standard dose of intra-articular TXA (2000?mg), and those in Group C were infused with TXA according to body weight (20?mg/kg) before tourniquet deflation and again 3 h later. Baseline characteristics and data collected at blood transfusion were compared. Differences among four time points (baseline, day 0, day 2, and day 5) were carried out using ANOVA. The hemoglobin levels at postoperative day 5 were 10.6?g/dL for Group A, 10.6?g/dL for Group B, and 10.7?g/dL for Group C. The drain output was 399?ml for Group A, 314?ml for Group B, and 305?ml for Group C ( p =?0.03). Group C had significantly less drain output than Group A after post hoc comparisons ( p =?0.05), whereas no significant difference was observed between Group A and B ( p =?0.09) or between Group B and C. The weight-adjusted dose of TXA administered intravenously significantly reduced the drain output but not the total blood loss when compared with the weight-adjusted dose of TXA administered intra-articularly. No significant difference was observed in the other parameters among the three groups. The Joint CUHK-NTEC CREC, CRE-2013.644-T . Registered 1 March 2014.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Blood Sparing Efficacy of Oral Tranexamic Acid in Primary Total Knee Arthroplasty: A Randomized Controlled Trial
Knee Surgery and Related Research
2017 .01
-
Effect of intravenous tranexamic acid on perioperative bleeding and transfusion in spine surgery: systematic review and meta-analysis of randomized controlled trials
Anesthesia and Pain Medicine
2019 .01
-
Tranexamic acid - a promising hemostatic agent with limitations: a narrative review
Korean Journal of Anesthesiology
2024 .08
-
Effectiveness and Safety of Tranexamic Acid in Spinal Deformity Surgery
대한신경외과학회지
2017 .01
-
Effect of Tranexamic Acid on Blood Loss and Blood Transfusion Reduction after Total Knee Arthroplasty
Knee Surgery and Related Research
2016 .01
-
Effect of tranexamic acid on hemodynamics after reverse shoulder arthroplasty according to the administration method - prospective multi-center randomized control study -
대한견주관절의학회 학술대회논문집
2019 .03
-
퇴행성 관절염 환자에게 동시에 시행하는 양측 인공 슬관절 전치환술에서 관절강 내 Tranexamic Acid 주입의 장점
대한정형외과학회지
2021 .12
-
Use of Topical Tranexamic Acid to Reduce Blood Loss in Single-Level Transforaminal Lumbar Interbody Fusion
Asian Spine Journal
2020 .01
-
Effects of tranexamic acid on the activity of glutamate transporter EAAT3
Anesthesia and Pain Medicine
2020 .01
-
Tranexamic Acid and Intraoperative and Postoperative Accumulative Bleeding in Elective Degenerative Spine Surgery
Yonsei Medical Journal
2022 .10
-
Tranexamic Acid Ameliorates Skin Hyperpigmentation by Downregulating Endothelin-1 Expression in Dermal Microvascular Endothelial Cells
Annals of Dermatology
2024 .06
-
Prophylactic tranexamic acid to reduce blood loss and related morbidities during hysterectomy: a systematic review and meta-analysis of randomized controlled trials
Obstetrics & Gynecology Science
2022 .09
-
역행성 견관절 전치환술에서 트라넥삼산의 출혈 및 수혈 감소 효과
대한정형외과학회지
2021 .10
-
Comparison of Blood Loss between Neutral Drainage with Tranexamic Acid and Negative Pressure Drainage without Tranexamic Acid Following Primary Total Knee Arthroplasty
Knee Surgery and Related Research
2016 .01
-
Effect of tranexamic acid on blood loss reduction in patients undergoing orthognathic surgery under hypotensive anesthesia: a single-center, retrospective, observational study
대한구강악안면외과학회지
2024 .04
-
Treatment of Infected Total Knee Arthroplasty
Knee Surgery and Related Research
2017 .01
-
Blood Management in Total Knee Arthroplasty: Updates and Debates
Knee Surgery and Related Research
2016 .01
-
Management of Blood Loss in Hip Arthroplasty: Korean Hip Society Current Consensus
Hip and Pelvis
2017 .06
-
Unicompartmental knee arthroplasty and revision total knee arthroplasty have a lower risk of venous thromboembolism disease at 30?days than primary total knee arthroplasty
Knee Surgery and Related Research
2020 .01
-
Diabetes mellitus does not increase the risk of knee stiffness after total knee arthroplasty: a meta-analysis of 7 studies including 246 053 cases
Knee Surgery and Related Research
2019 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0