지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Resistance to extended-spectrum cephalosporin in Enterobacteriaceae is increasingly prevalent in South Korea. This study aims to explore the distribution of AmpC genes in Proteus mirabilis isolated from stray and hospital-admitted companion animals in South Korea. AmpC β-lactamases hold clinical significance due to its potential to facilitate antimicrobial resistance to cefoxitin, cefazolin, and most penicillins. A total of 163 bacterial isolates belonging to the Enterobacteriaceae family were collected from dogs (n = 158) and cats (n=5). Of them, 134 isolates were from hospital-admitted animals, while 29 isolates from stray animals. Boronic acid tests and antimicrobial susceptibility tests were conducted for an initial screening to detect AmpC β-lactamase resistant P. mirabilis. Gene-specific PCRs were conducted to identify the type of AmpC genes, which include six groups (MOXM, CITM, DHAM, ACCM, EBCM, and FOXM), in the resistant isolates. The boronic acid disk tests revealed 45 (27.6%) positive isolates out of 163 isolates tested. Of these 45 isolates, six were determined to harbor the EBCM gene, 13 for CITM, one for FOXM, and one for DHAM by single detection PCR. No isolates carried for ACCM or MOXM. Thus, a total of 21 out of 163 isolates (12.9%) were demonstrated to possess AmpC genes. No isolates contain more than one group of AmpC gene family. A significantly higher percentage of P. mirabilis was found to possess AmpC genes compared to past studies. Therefore, the increasing trend in antimicrobial resistance in P. mirabilis indicates a dire need to monitor antimicrobial prescription in the veterinary field.
목차
등록된 정보가 없습니다.
참고문헌 (15)
참고문헌 신청
Armbruster CE / 2018 / Pathogenesis of Proteus mirabilis Infection / EcoSal Plus 8(1)
Pierre Bogaerts / 2015 / Characterization of ESBL- and AmpC-Producing Enterobacteriaceae from Diseased Companion Animals in Europe / Microbial Drug Resistance 21(6):643~650
CLSI / 2017 / Performance Standards for Antimicrobial Susceptibility Testing; Approved Standard / CLSI
Fam N / 2013 / Detection of Plasmid-Mediated AmpC Beta-Lactamases in Clinically Significant Bacterial Isolates in a Research Institute Hospital in Egypt / Life Sci 10(2):2294~2304
Mai M. Helmy / 2014 / Phenotypic and Molecular Characterization of Plasmid Mediated AmpCβ-Lactamases amongEscherichia coli,Klebsiellaspp., andProteus mirabilisIsolated from Urinary Tract Infections in Egyptian Hospitals / BioMed Research International 2014:1~8
Pierre Bogaerts / 2015 / Characterization of ESBL- and AmpC-Producing Enterobacteriaceae from Diseased Companion Animals in Europe / Microbial Drug Resistance 21(6):643~650
CLSI / 2017 / Performance Standards for Antimicrobial Susceptibility Testing; Approved Standard / CLSI
Fam N / 2013 / Detection of Plasmid-Mediated AmpC Beta-Lactamases in Clinically Significant Bacterial Isolates in a Research Institute Hospital in Egypt / Life Sci 10(2):2294~2304
Mai M. Helmy / 2014 / Phenotypic and Molecular Characterization of Plasmid Mediated AmpCβ-Lactamases amongEscherichia coli,Klebsiellaspp., andProteus mirabilisIsolated from Urinary Tract Infections in Egyptian Hospitals / BioMed Research International 2014:1~8
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