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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 1,135 - 1,143 (9page)
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초록· 키워드
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Purpose: Candida albicans (C. albicans) and Proteus species are causative agents in a variety of opportunistic nosocomial infections,and their ability to form biofilms is known to be a virulence factor. In this study, the influence of co-cultivation with Proteus vulgaris (P. vulgaris) and Proteus mirabilis (P. mirabilis) on C. albicans biofilm formation and its underlying mechanisms were examined.
Materials and Methods: XTT reduction assays were adopted to measure biofilm formation, and viable colony counts were performedto quantify yeast growth. Real-time reverse transcriptase polymerase chain reaction was used to evaluate the expression of yeast-specific genes (rhd1 and rbe1), filament formation inhibiting genes (tup1 and nrg1), and hyphae-related genes (als3, ece1, hwp1, and sap5).
Results: Candida biofilm formation was markedly inhibited by treatment with either living or heat-killed P. vulgaris and P. mirabilis.
Proteus-cultured supernatant also inhibited Candida biofilm formation. Likewise, treatment with live P. vulgaris or P. mirabilisor with Proteus-cultured supernatant decreased expression of hyphae-related C. albicans genes, while the expression of yeast-specific genes and the filament formation inhibiting genes of C. albicans were increased. Heat-killed P. vulgaris and P. mirabilistreatment, however, did not affect the expression of C. albicans morphology-related genes.
Conclusion: These results suggest that secretory products from P. vulgaris and P. mirabilis regulate the expression of genes related to morphologic changes in C. albicans such that transition from the yeast form to the hyphal form can be inhibited.
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참고문헌 (28)
참고문헌 신청
Adam B / 2002 / Mixed species biofilms of Candida albicans and Staphylococcus epidermidis / J Med Microbiol 51 : 344 ~ 349
Braun BR / 2000 / Identification and characterization of TUP1-regulated genes in Candida albicans / Genetics 156 : 31 ~ 44
Budtz-Jørgensen E / 2000 / Effects of an oral health program on the occurrence of oral candidosis in a long-term care facility / Community Dent Oral Epidemiol 28 : 141 ~ 149
Costerton JW / 1978 / How bacteria stick / Sci Am 238 : 86 ~ 95
Costerton JW / 1995 / Microbial biofilms / Annu Rev Microbiol 49 : 711 ~ 745
Braun BR / 2000 / Identification and characterization of TUP1-regulated genes in Candida albicans / Genetics 156 : 31 ~ 44
Budtz-Jørgensen E / 2000 / Effects of an oral health program on the occurrence of oral candidosis in a long-term care facility / Community Dent Oral Epidemiol 28 : 141 ~ 149
Costerton JW / 1978 / How bacteria stick / Sci Am 238 : 86 ~ 95
Costerton JW / 1995 / Microbial biofilms / Annu Rev Microbiol 49 : 711 ~ 745
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