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자료유형
학술저널
저자정보
Abbas Maleki (Ilam University of Medical Science) Afra Khosravi (Ilam University of Medical Science) Sobhan Ghafourian (Ilam University of Medical Science) Iraj Pakzad (Ilam University of Medical Science) Shiva Hosseini (Ilam University of Medical Science) Rashid Ramazanzadeh (Kurdistan University of Medical Sciences) Nourkhoda Sadeghifard (Ilam University of Medical Science)
저널정보
질병관리본부 Osong Public Health and Research Persptectives Osong Public Health and Research Persptectives Vol.6 No.3
발행연도
2015.1
수록면
201 - 204 (4page)

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Objectives: Widespread use of β-lactam antibiotics could cause resistance to this group of antibiotics in pathogenic bacteria through the production of the enzyme β-lactamases. The aimof this study is to determine themolecular detection of AmpC β-lactamases among clinical Escherichia coli isolated from Ilam hospitals in Ilam, Iran. Methods: One hundred and twelve clinical isolates of E. coli were collected from hospitalized patients and were identified by biochemical tests. They were evaluated for extended spectrum beta-lactamases (ESBLs) production, and the positive strains were subjected to AmpC enzymes; for detection of AmpC cluster genes, multiplex polymerase chain reaction was applied. Results: The analysis showed 62.5% of isolates were ESBLs positive and that five strains revealed the AmpC cluster genes. This is the first report of FOXM cluster genes in E. coli in Iran. Conclusion: Based on our results, the prevalence of AmpC β-lactamases is increasing in Iran, which caused failure in antibiotic therapy. So, the current study recommended the revision of antibiotic policy in Iranian hospitals.

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