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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 417 - 421 (5page)
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We describe a confusing case of GATA3-positive adnexal adenocarcinoma with a potential pitfall of leading to a misdiagnosis of urothelial carcinoma. A 62-year-old male presented with a subcutaneous nodule on the right lower abdomen around a scar from surgery for urothelial carcinoma in the right urinary tract, which had been resected 8 years previously. Histologically, atypical cells possessing ample cytoplasm and partial intracytoplasmic lumens were densely grouped in the subcutaneous expansive nodule and bilateral inguinal lymph nodes dissected. Decapitation secretion could not be seen. Neoplastic cells were positive for CK7, GATA3, and GCDFP15, and negative for CK5/6, CK20, p63, CD10, PAX8, HER-2, and uroplakin-Ⅱ. Neoplastic cells in the urothelium and the metastasized lung were positive for CK7, CK5/6, and GATA3, and negative for CK20, p63, GCDFP15, and TTF-1. A variable level of GATA3 expression in malignant tumors with apocrine and eccrine differentiation should be recognized by dermatologists.
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참고문헌 (16)
참고문헌 신청
Massi D / 2018 / WHO classification of skin tumours / International Agency for Research on Cancer :155~156
Pardal J / 2017 / GATA3 and MYB expression in cutaneous adnexal neoplasms / Am J Dermatopathol 39:279~286
Higgins JP / 2007 / Placental S100(S100P)and GATA3 : markers for transitional epithelium and urothelial carcinoma discovered by complementary DNA microarray / Am J Surg Pathol 31:673~680
Miettinen M / 2014 / GATA3 : a multispecific but potentially useful marker in surgical pathology : a systematic analysis of 2500 epithelial and nonepithelial tumors / Am J Surg Pathol 38:13~22
Liu H / 2012 / Immunohistochemical evaluation of GATA3 expression in tumors and normal tissues : a useful immunomarker for breast and urothelial carcinomas / Am J Clin Pathol 138:57~64
Pardal J / 2017 / GATA3 and MYB expression in cutaneous adnexal neoplasms / Am J Dermatopathol 39:279~286
Higgins JP / 2007 / Placental S100(S100P)and GATA3 : markers for transitional epithelium and urothelial carcinoma discovered by complementary DNA microarray / Am J Surg Pathol 31:673~680
Miettinen M / 2014 / GATA3 : a multispecific but potentially useful marker in surgical pathology : a systematic analysis of 2500 epithelial and nonepithelial tumors / Am J Surg Pathol 38:13~22
Liu H / 2012 / Immunohistochemical evaluation of GATA3 expression in tumors and normal tissues : a useful immunomarker for breast and urothelial carcinomas / Am J Clin Pathol 138:57~64
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