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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2015.10
- 수록면
- 275 - 303 (29page)
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초록· 키워드
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Ginseng, the root of Pctnax ginseng (P. ginseng), is an oriental traditional herb used in treatment of several human disorder. Ginsenoside, the active compound of P. ginseng have reported as anti-inflammation, anti-osteoporosis and anti-tumour activity. However, the combined in-silico and in-vitro anti-lung cancer activity of compound K (CK) has not been reported so far. Therefore, the purpose of this study was to evaluate the anti-lung cancer activity of CK using in silico docking study followed by in-vitro validation using human lung cancer A549 cells. In recent study we reported that CK could impede growth, and proliferation as well as induce apoptosis in human lung cancer A549 cells. The in-silico study for CK and H-Ras protein was performed by molecular docking simulation. On the other hand, anti-proliferative, anti-migratory and apoptotic activity of C-K were measured by BrdU assay, wound-healing assay and Hoechst-staining respectively. We also evaluated the inhibitory activity of CK on mRNA expression levels of EGFR, H-Ras and ELK1 by realtime PCR (RT-PCR) analysis. Our molecular docking results showed that compared with a control drug (Erlotinib), CK strongly interact with H-Ras protein with good binding energy. Also, our in-vitro results revealed that C-K had the capability to suppress the proliferation, as well as decrease cell migration in A549 cells. Moreover, CK-induced apoptosis and could be blocked mRNA expression level of aforementioned genes in human lung cancer A549 cells. Taken together, these results indicate that CK exerts antiproliferative effects on A549 cells in-vitro and in-silico via EGFR/H-Ras signals.
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UCI(KEPA) : I410-ECN-0101-2016-519-002373912