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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2015.10
- 수록면
- 354 - 373 (20page)
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Cancer is a leading cause of death worldwide. Although numerous anticancer drugs are available, their lack of tumor-targeting and low water-solubility are major drawbacks to use in cancer treatment. Conjugation of anticancer drugs with water-soluble polymers has been exhibited increased water-solubility of hydrophobic drugs, reduced normal cell cytotoxicity, increased accumulation in tumor tissues by passive targeting, and enhanced permeation and retention (EPR) effect. This study, we used ginsenoside compound K (CK) which is triterpenoid found in oriental medical plant- Panax ginseng Meyer. CK is one of the major metabolite after oral administration of crude extracts, reaches systemic circulation and reported for various pharmacological activities. However, solubility and targeted delivery is the major drawback to use of CK in clinical trials. We attempted to developed polymer CK conjugates to enhance its solubility and targeted delivery. To this, hydrophobic CK was covalently conjugated to the hydrophilic glycol chitosan (GC) and polyethylene glycol (PEG) through an acid-labile ester linkage. The resulting GC-CK and PEG-CK conjugates were characterized by H NMR and FTIR. It formed self-assembled spherical shape nanoparticles in water. The conjugates were greatly increased solubility of CK. From in vitro release experiment, release of CK was enhanced under pH 5, whereas it was dramatically decreased under physiological conditions (pH 7.4) is similar to what would be expected in extracellular solid tumor tissues and intracellular endosomes and lysosomes. In vitro cytotoxicity assays revealed that conjugates exhibited higher cytotoxicity in HT29, HepG2, and HT22 cell lines and maintained good cell viability in RAW264.7 cells. These results suggest that these conjugates may be potentially useful as a tumor-specific delivery vehicle which may enhance the overall efficacy of CK.
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Creatine Kinase (CK)-MB-to-Total-CK Ratio: a Laboratory Indicator for Primary Cancer Screening
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Cytokeratin 15 is an Effective Indicator for Progression and Malignancy of Esophageal Squamous Cell Carcinomas
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AKT1-targeted proapoptotic activity of compound K in human breast cancer cells
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Effects of EGFR, CK19, CK20 and Survinin Gene Expression on Radiotherapy Results in Patients with Locally Advanced Head and Neck Cancer
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Ginsenoside compound K ameliorates palmitate-induced atrophy in C2C12 myotubes via promyogenic effects and AMPK/autophagy-mediated suppression of endoplasmic reticulum stress
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The skin protective effects of compound K, a metabolite of ginsenoside Rb1 from Panax ginseng
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In silico and In vitro Analysis of Anti-lung cancer Activity of Compound K in EGF-induced A549 Cells
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Estrogen Induces CK2α Activation via Generation of Reactive Oxygen Species
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Compound K, a ginsenoside metabolite, plays an antiinflammatory role in macrophages by targeting the AKT1-mediated signaling pathway
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Compound K, a Metabolite of Ginsenosides, Attenuates Collagen-induced Arthritis in Mice
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Epithelial Autoantigen-Specific IgG Antibody Enhances Eosinophil Extracellular Trap Formation in Severe Asthma
Allergy, Asthma & Immunology Research
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Protein target identification of ginsenosides in skeletal muscle tissues: discovery of natural small-molecule activators of muscle-type creatine kinase
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Association Between Cytokeratin 19-Specific IgG and Neutrophil Activation in Asthma
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Elevation of serum creatine kinase during methimazole treatment of Graves disease in a 13-year-old girl and a literature review of similar cases
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Nrf2-mediated activation of HO-1 is required in the blocking effect of compound K, a ginseng saponin metabolite, against oxidative stress damage in ARPE-19 human retinal pigment epithelial cells
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Enhanced antidiabetic efficacy and safety of compound K/βb-cyclodextrin inclusion complex in zebrafish
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The effect of ultrasonic file sizes on smear layer removal in passive ultrasonic irrigation
대한치과의사협회지
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Compound K attenuates hyperglycemia by enhancing glucagon-like peptide-1 secretion through activating TGR5 via the remodeling of gut microbiota and bile acid metabolism
Journal of Ginseng Research
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A prebiotic fiber increases the formation and subsequent absorption of compound K following oral administration of ginseng in rats
Journal of Ginseng Research
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UCI(KEPA) : I410-ECN-0101-2016-519-002373967