지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.4
- 수록면
- 218 - 224 (7page)
이용수
초록· 키워드
오류제보하기
Background: Compound K (CK) is a ginsenoside, a metabolite of Panax ginseng. There is interest both in increasing skin health and antiaging using natural skin care products. In this study, we explored the possibility of using CK as a cosmetic ingredient.
Methods: To assess the antiaging effect of CK, RT-PCR was performed, and expression levels of matrix metalloproteinase-1, cyclooxygenase-2, and type I collagen were measured under UVB irradiation conditions. The skin hydrating effect of CK was tested by RT-PCR, and its regulation was explored through immunoblotting. Melanin content, melanin secretion, and tyrosinase activity assays were performed.
Results: CK treatment reduced the production of matrix metalloproteinase-1 and cyclooxygenase-2 in UVB irradiated NIH3T3 cells and recovered type I collagen expression level. Expression of skin hydrating factorsdfilaggrin, transglutaminase, and hyaluronic acid synthases-1 and -2dwere augmented by CK and were modulated through the inhibitor of κBα, c-Jun N-terminal kinase, or extracellular signalregulated kinases pathway. In the melanogenic response, CK did not regulate tyrosinase activity and melanin secretion, but increased melanin content in B16F10 cells was observed.
Conclusion: Our data showed that CK has antiaging and hydrating effects. We suggest that CK could be used in cosmetic products to protect the skin from UVB rays and increase skin moisture level.
Methods: To assess the antiaging effect of CK, RT-PCR was performed, and expression levels of matrix metalloproteinase-1, cyclooxygenase-2, and type I collagen were measured under UVB irradiation conditions. The skin hydrating effect of CK was tested by RT-PCR, and its regulation was explored through immunoblotting. Melanin content, melanin secretion, and tyrosinase activity assays were performed.
Results: CK treatment reduced the production of matrix metalloproteinase-1 and cyclooxygenase-2 in UVB irradiated NIH3T3 cells and recovered type I collagen expression level. Expression of skin hydrating factorsdfilaggrin, transglutaminase, and hyaluronic acid synthases-1 and -2dwere augmented by CK and were modulated through the inhibitor of κBα, c-Jun N-terminal kinase, or extracellular signalregulated kinases pathway. In the melanogenic response, CK did not regulate tyrosinase activity and melanin secretion, but increased melanin content in B16F10 cells was observed.
Conclusion: Our data showed that CK has antiaging and hydrating effects. We suggest that CK could be used in cosmetic products to protect the skin from UVB rays and increase skin moisture level.
목차
ABSTRACT
1. Introduction
2. Materials and methods
3. Results and discussion
References
참고문헌 (52)
참고문헌 신청
[학술지(정기간행물)] - Kanlayavattanakul M / 2016 / Jasmine rice panicle: a safe and efficient natural ingredient for skin aging treatments / J Ethnopharmacol 193 : 607 ~ 616
[학술지(정기간행물)] - Kim YM / 2016 / Anti-wrinkle effects of a tuna heart $H_2O$ fraction on Hs27 human fibroblasts / Int J Mol Med 37 : 92 ~ 98
[학술지(정기간행물)] - Farage M / 2008 / Intrinsic and extrinsic factors in skin ageing: a review / Int J Cosmet Sci 30 : 87 ~ 95
[학술지(정기간행물)] - Quan T / 2009 / Matrix-degrading metalloproteinases in photoaging / J Investig Dermatol Symp Proc 14 : 20 ~ 24
[학술지(정기간행물)] - Fisher GJ / 1997 / Pathophysiology of premature skin aging induced by ultraviolet light / N Engl J Med 337 : 1419 ~ 1429
[학술지(정기간행물)] - Kim YM / 2016 / Anti-wrinkle effects of a tuna heart
[학술지(정기간행물)] - Farage M / 2008 / Intrinsic and extrinsic factors in skin ageing: a review / Int J Cosmet Sci 30 : 87 ~ 95
[학술지(정기간행물)] - Quan T / 2009 / Matrix-degrading metalloproteinases in photoaging / J Investig Dermatol Symp Proc 14 : 20 ~ 24
[학술지(정기간행물)] - Fisher GJ / 1997 / Pathophysiology of premature skin aging induced by ultraviolet light / N Engl J Med 337 : 1419 ~ 1429
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