지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한천식알레르기학회(구 대한알레르기학회) Allergy, Asthma & Immunology Research Allergy, Asthma & Immunology Research Vol.14 No.5
- 발행연도
- 2022.9
- 수록면
- 479 - 493 (15page)
- DOI
- 10.4168/aair.2022.14.5.479
이용수
초록· 키워드
오류제보하기
Purpose: There have been autoimmune mechanisms for the pathogenesis of severe asthma (SA) involving epithelial autoantigen-specific antibodies. This study aimed to find the function of these antibodies in the formation of eosinophil extracellular traps (EETs), contributing to the development of SA.
Methods: Patients with SA (n = 11), those with patients with nonsevere asthma (NSA, n = 41), and healthy controls (HCs, n = 26) were recruited to evaluate levels of epithelial antigens and autoantigen-specific antibodies. Moreover, the significance of epithelial autoantigen-specific antibodies in association with EET production was investigated ex vivo and in vivo.
Results: Significantly higher levels of serum cytokeratin (CK) 18 and CK18-specific IgG were observed in patients with SA than in those with NSA (P = 0.001 and P = 0.031, respectively), while no differences were found in serum CK19 or CK19-specific immunoglobulin G (IgG). Moreover, levels of serum CK18 were positively correlated with total eosinophil counts (r = 0.276, P = 0.048) in asthmatics, while a negative correlation was noted between levels of serum CK18 and forced expiratory volume in 1 second (FEV1) %. In the presence of CK18-specific IgG, peripheral eosinophils from asthmatics released EETs, which further increased CK18 production from airway epithelial cells. In severe asthmatic mice, CK18 expression and CK18-specific IgG production were enhanced in the lungs, where EET treatment enhanced CK18 expression and CK18-specific IgG production, either of which was not suppressed by dexamethasone.
Conclusions: These suggest that EETs could enhance epithelial autoantigen (CK18)-induced autoimmune responses, further stimulating EET production and type 2 airway responses, which is a new therapeutic target for SA.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Association Between Cytokeratin 19-Specific IgG and Neutrophil Activation in Asthma
Allergy, Asthma & Immunology Research
2024 .07
-
Creatine Kinase (CK)-MB-to-Total-CK Ratio: a Laboratory Indicator for Primary Cancer Screening
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Cytokeratin 15 is an Effective Indicator for Progression and Malignancy of Esophageal Squamous Cell Carcinomas
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
Defining the Normal Trends of Serum Creatine Kinase Levels Following Spinal Surgery
Asian Spine Journal
2019 .01
-
Effects of EGFR, CK19, CK20 and Survinin Gene Expression on Radiotherapy Results in Patients with Locally Advanced Head and Neck Cancer
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Enhanced Efficacies of Ginsenoside Compound K conjugated with Polymers in cancer cells
대한동의병리학회 학술대회논문집
2015 .10
-
Ginsenoside compound K ameliorates palmitate-induced atrophy in C2C12 myotubes via promyogenic effects and AMPK/autophagy-mediated suppression of endoplasmic reticulum stress
Journal of Ginseng Research
2022 .05
-
Estrogen Induces CK2α Activation via Generation of Reactive Oxygen Species
대한의생명과학회지
2019 .03
-
Compound K, a Metabolite of Ginsenosides, Attenuates Collagen-induced Arthritis in Mice
대한류마티스학회지
2015 .01
-
AKT1-targeted proapoptotic activity of compound K in human breast cancer cells
Journal of Ginseng Research
2019 .10
-
The skin protective effects of compound K, a metabolite of ginsenoside Rb1 from Panax ginseng
Journal of Ginseng Research
2018 .04
-
Immune Cell-Mediated Autoimmune Responses in Severe Asthma
Yonsei Medical Journal
2024 .04
-
In silico and In vitro Analysis of Anti-lung cancer Activity of Compound K in EGF-induced A549 Cells
대한동의병리학회 학술대회논문집
2015 .10
-
Compound K, a ginsenoside metabolite, plays an antiinflammatory role in macrophages by targeting the AKT1-mediated signaling pathway
Journal of Ginseng Research
2019 .01
-
Enhanced antidiabetic efficacy and safety of compound K/βb-cyclodextrin inclusion complex in zebrafish
Journal of Ginseng Research
2017 .01
-
Elevation of serum creatine kinase during methimazole treatment of Graves disease in a 13-year-old girl and a literature review of similar cases
Annals of Pediatirc Endocrinology & Metabolism
2015 .01
-
Nrf2-mediated activation of HO-1 is required in the blocking effect of compound K, a ginseng saponin metabolite, against oxidative stress damage in ARPE-19 human retinal pigment epithelial cells
Journal of Ginseng Research
2023 .03
-
The effect of ultrasonic file sizes on smear layer removal in passive ultrasonic irrigation
대한치과의사협회지
2020 .04
-
Organ Correlation in IgG4-Related Diseases
Journal of Korean Medical Science
2015 .01
-
Eosinophil Extracellular Traps Pave the Way for the Identification of Novel Therapeutics in Severe Asthma
Allergy, Asthma & Immunology Research
2022 .09
이 논문의 저자 정보
최근 본 자료
댓글(0)
0