지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제25권 제3호
- 발행연도
- 2021.1
- 수록면
- 227 - 237 (11page)
이용수
초록· 키워드
오류제보하기
Carbon monoxide (CO) is a cardioprotectant and potential cardiovascular therapeutic agent. Human cardiac fibroblasts (HCFs) are important determinants of myocardial structure and function. Large-conductance Ca2+-activated K+ (BK) channel is a potential therapeutic target for cardiovascular disease. We investigated whether CO modulates BK channels and the signaling pathways in HCFs using whole-cell mode patch-clamp recordings. CO-releasing molecules (CORMs; CORM-2 and CORM- 3) significantly increased the amplitudes of BK currents (IBK ). The CO-induced stimulating effects on IBK were blocked by pre-treatment with specific nitric oxide synthase (NOS) blockers (L-NG-monomethyl arginine citrate and L-NG-nitroarginine methyl ester). 8-bromo-cyclic GMP increased IBK. KT5823 (inhibits PKG) or ODQ (inhibits soluble guanylate cyclase) blocked the CO-stimulating effect on IBK. Moreover, 8-bromo-cyclic AMP also increased IBK, and pre-treatment with KT5720 (inhibits PKA) or SQ22536 (inhibits adenylate cyclase) blocked the CO effect. Pre-treatment with Nethylmaleimide (a thiol-alkylating reagent) also blocked the CO effect on IBK, and DLdithiothreitol (a reducing agent) reversed the CO effect. These data suggest that CO activates IBK through NO via the NOS and through the PKG, PKA, and S-nitrosylation pathways
목차
등록된 정보가 없습니다.
참고문헌 (67)
참고문헌 신청
Marchewka J / 2017 / Cardiological aspects of carbon monoxide poisoning / Folia Med Cracov 57:75~85
Peers C / 2012 / Carbon monoxide : a vital signalling molecule and potent toxin in the myocardium / J Mol Cell Cardiol 52:359~365
André L / 2011 / Carbon monoxide exposure enhances arrhythmia after cardiac stress : involvement of oxidative stress / Basic Res Cardiol 106:1235~1246
Dallas ML / 2012 / Carbon monoxide induces cardiac arrhythmia via induction of the late Na+current / Am J Respir Crit Care Med 186:648~656
Gandini C / 2001 / Carbon monoxide cardiotoxicity / J Toxicol Clin Toxicol 39:35~44
Peers C / 2012 / Carbon monoxide : a vital signalling molecule and potent toxin in the myocardium / J Mol Cell Cardiol 52:359~365
André L / 2011 / Carbon monoxide exposure enhances arrhythmia after cardiac stress : involvement of oxidative stress / Basic Res Cardiol 106:1235~1246
Dallas ML / 2012 / Carbon monoxide induces cardiac arrhythmia via induction of the late Na+current / Am J Respir Crit Care Med 186:648~656
Gandini C / 2001 / Carbon monoxide cardiotoxicity / J Toxicol Clin Toxicol 39:35~44
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Carbon monoxide activation of delayed rectifier potassium currents of human cardiac fibroblasts through diverse pathways
The Korean Journal of Physiology & Pharmacology
2022 .01
-
Effects of hydrogen peroxide on voltage-dependent K+ currents in human cardiac fibroblasts through protein kinase pathways
The Korean Journal of Physiology & Pharmacology
2016 .05
-
Hematological and microbial analysis on a Holstein heifer with infectious bovine keratoconjunctivitis
한국가축위생학회지
2020 .01
-
Carbon monoxide–releasing molecule-3: Amelioration of renal ischemia reperfusion injury in a rat model
Investigative and Clinical Urology
2020 .01
-
Ginsenoside Re inhibits pacemaker potentials via adenosine triphosphate-sensitive potassium channels and the cyclic guanosine monophosphate/nitric oxide-dependent pathway in cultured interstitial cells of Cajal from mouse small intestine
Journal of Ginseng Research
2015 .10
-
17Beta-Estradiol Inhibits Calcium-Activated Potassium Channel Expressions in Rat Whole Bladder
International Neurourology Journal
2016 .01
-
Total ginsenosides suppress monocrotaline-induced pulmonary hypertension in rats : involvement of nitric oxide and mitogen-activated protein kinase pathways
Journal of Ginseng Research
2016 .07
-
Carbon Monoxide Ameliorates 6-Hydroxydopamine-Induced Cell Death in C6 Glioma Cells
Biomolecules & Therapeutics(구 응용약물학회지)
2018 .01
-
Pituitary Adenylate Cyclase-activating Polypeptide Inhibits Pacemaker Activity of Colonic Interstitial Cells of Cajal
The Korean Journal of Physiology & Pharmacology
2015 .09
-
Carbon monoxide releasing molecule-2 protects mice against acute kidney injury through inhibition of ER stress
The Korean Journal of Physiology & Pharmacology
2018 .09
-
Carbon monoxide poisoning-induced cardiomyopathy from charcoal at a barbecue restaurant: a case report
대한직업환경의학회지
2015 .04
-
Comparison of electrophysiological effects of calcium channel blockers on cardiac repolarization
The Korean Journal of Physiology & Pharmacology
2016 .01
-
Effect of aortic smooth muscle BK channels on mediating chronic intermittent hypoxia-induced vascular dysfunction
The Korean Journal of Physiology & Pharmacology
2024 .09
-
KCl Mediates $K^+$ Channel-Activated Mitogen-Activated Protein Kinases Signaling in Wound Healing
Archives of plastic surgery : APS
2015 .01
-
Role of potassium channels in female reproductive system
Obstetrics & Gynecology Science
2020 .01
-
T-Type Calcium Channels Are Required to Maintain Viability of Neural Progenitor Cells
Biomolecules & Therapeutics(구 응용약물학회지)
2018 .01
-
Compound K Inhibits Interleukin-1β-induced Expression of Inflammatory Mediators and Matrix Metalloproteinases by Inhibiting Mitogen-activated Protein Kinase Activation in Chondrocytes
대한류마티스학회지
2018 .01
-
호기 중 일산화탄소 농도에 따른 양도락 상의 변화 연구 (후향적 증례연구)
대한한의학회지
2020 .03
-
Protein Kinase CK2 Modulates the Calcium Sensitivity of Type 3 Small-conductance Calcium-activated Potassium Channels in Colonic Platelet-derived Growth Factor Receptor Alpha-positive Cells From Streptozotocin-induced Diabetic Mice
Journal of Neurogastroenterology and Motility (JNM)
2023 .04
-
Docosahexaenoic acid reduces adenosine triphosphate-induced calcium influx via inhibition of store-operated calcium channels and enhances baseline endothelial nitric oxide synthase phosphorylation in human endothelial cells
The Korean Journal of Physiology & Pharmacology
2019 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0