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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 175 - 181 (7page)
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초록· 키워드
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Carbon monoxide (CO) is well-known as toxic gas and intrinsic signaling molecule such as neurotransmitter and blood vessel relaxant. Recently, it has been reported that low concentration of CO exerts therapeutic actions under various pathological conditions including liver failure, heart failure, gastric cancer, and cardiac arrest. However, little has been known about the effect of CO in neurodegenerative diseases like Parkinson's disease (PD). To test whether CO could exert a beneficial action during oxidative cell death in PD, we examined the effects of CO on 6-hydroxydopamine (6-OHDA)-induced cell death in C6 glioma cells. Treatment of CO-releasing molecule-2 (CORM-2) significantly attenuated 6-OHDA-induced apoptotic cell death in a dose-dependent manner. CORM-2 treatment decreased Bax/Bcl2 ratio and caspase-3 activity, which had been increased by 6-OHDA. CORM-2 increased phosphorylation of NF-E2-related factor 2 (Nrf2) which is a transcription factor regulating antioxidant proteins. Subsequently, CORM-2 also increased the expression of heme oxygenase-1 and superoxide dismutases (CuZnSOD and MnSOD), which were antioxidant enzymes regulated by Nrf2. These results suggest that CO released by CORM-2 treatment may have protective effects against oxidative cell death in PD through the potentiation of cellular adaptive survival responses via activation of Nrf2 and upregulation of heme oxygenase-1, leading to increasing antioxidant defense capacity.
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참고문헌 (42)
참고문헌 신청
Babu, D. / 2015 / Antioxidant potential of CORM-A1 and resveratrol during TNF-alpha/cycloheximide-induced oxidative stress and apoptosis in murine intestinal epithelial MODE-K cells / Toxicol. Appl. Pharmacol. 288:161~178
Basuroy, S. / 2013 / CORM-A1 prevents blood-brain barrier dysfunction caused by ionotropic glutamate receptor-mediated endothelial oxidative stress and apoptosis / Am. J. Physiol. Cell Physiol. 304:C1105~C1115
Blandini, F. / 2008 / The 6-hydroxydopamine model: news from the past / Parkinsonism Relat. Disord. 14:S124~S129
Caumartin, Y. / 2011 / Carbon monoxide-releasing molecules protect against ischemia-reperfusion injury during kidney transplantation / Kidney Int. 79:1080~1089
Chapman, J. T. / 2001 / Carbon monoxide attenuates aeroallergen-induced inflammation in mice / Am. J. Physiol. Lung Cell Mol. Physiol. 281:L209~L216
Basuroy, S. / 2013 / CORM-A1 prevents blood-brain barrier dysfunction caused by ionotropic glutamate receptor-mediated endothelial oxidative stress and apoptosis / Am. J. Physiol. Cell Physiol. 304:C1105~C1115
Blandini, F. / 2008 / The 6-hydroxydopamine model: news from the past / Parkinsonism Relat. Disord. 14:S124~S129
Caumartin, Y. / 2011 / Carbon monoxide-releasing molecules protect against ischemia-reperfusion injury during kidney transplantation / Kidney Int. 79:1080~1089
Chapman, J. T. / 2001 / Carbon monoxide attenuates aeroallergen-induced inflammation in mice / Am. J. Physiol. Lung Cell Mol. Physiol. 281:L209~L216
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