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논문 기본 정보

자료유형
학술저널
저자정보
김준모 (순천향대학교) 송기성 (순천향대학교) Boqun Xu (Yale University) Tong Wang (Yale University)
저널정보
대한산부인과학회 Obstetrics & Gynecology Science Obstetrics & Gynecology Science 제63권 제5호
발행연도
2020.1
수록면
565 - 576 (12page)

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Potassium channels are widely expressed in most types of cells in living organisms and regulate the functions ofa variety of organs, including kidneys, neurons, cardiovascular organs, and pancreas among others. However, thefunctional roles of potassium channels in the reproductive system is less understood. This mini-review providesinformation about the localization and functions of potassium channels in the female reproductive system. Fivetypes of potassium channels, which include inward-rectifying (Kir), voltage-gated (Kv), calcium-activated (KCa), 2-poredomain (K2P), and rapidly-gating sodium-activated (Slo) potassium channels are expressed in the hypothalamus,ovaries, and uterus. Their functions include the regulation of hormone release and feedback by Kir6.1 and Kir6.2,which are expressed in the luteal granulosa cells and gonadotropin-releasing hormone neurons respectively, andregulate the functioning of the hypothalamus?pituitary?ovarian axis and the production of progesterone. Bothchannels are regulated by subtypes of the sulfonylurea receptor (SUR), Kir6.1/SUR2B and Kir6.2/SUR1. Kv and Slo2.1affect the transition from uterine quiescence in late pregnancy to the state of strong myometrial contractions inlabor. Intermediate- and small-conductance KCa modulate the vasodilatation of the placental chorionic plate resistancearteries via the secretion of nitric oxide and endothelium-derived hyperpolarizing factors. Treatment with specificchannel activators and inhibitors provides information relevant for clinical use that could help alter the functions ofthe female reproductive system.

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